Differential glycosaminoglycan expression and hyaluronan homeostasis in juvenile hyaline fibromatosis

Background Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive disease characterized histologically by deposition of hyaline material and clinically by multiple skin lesions. Clarification of the molecular and structural changes involved in JHF skin lesions may unravel targets for pharmacotherapy. Objective We sought to investigate the expression of glycosaminoglycans and their metabolizing enzymes in lesional as compared with...