Original paper
Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo
Volume: 45, Issue: 3, Pages: 336 - 343
Published: Feb 1, 2012
Abstract
As many new active pharmaceutical ingredients are poorly water soluble, solubility enhancers are one possibility to overcome the hurdles of drug dissolution and absorption in oral drug delivery. In the present work a novel solubility enhancing excipient (Soluplus®) was tested for its capability to improve intestinal drug absorption. BCS class II compounds danazol, fenofibrate and itraconazole were tested both in vivo in beagle dogs and in vitro...
Paper Details
Title
Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo
Published Date
Feb 1, 2012
Volume
45
Issue
3
Pages
336 - 343
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Notes
History