Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

Stéphanie Debette and colleagues report the results of a genome-wide association study of cervical artery dissection, a major cause of ischemic stroke in young adults. They show that common variation in PHACTR1, previously associated with lower risk of migraine and increased risk of myocardial infarction, is associated with reduced risk of cervical artery dissection. Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral...