The protective effects of melatonin against water avoidance stress-induced mast cell degranulation in dermis

Nontraumatic psychological water avoidance stress has been shown to induce mucosal degeneration, inflammatory cell infiltration and mast cell degranulation in stomach, ileum, colon and urinary bladder. Many skin disorders, such as atopic dermatitis and psoriasis, worsen during stress and seem to be related with infiltration and activation of mast cells releasing vasoactive and proinflammatory mediators. Melatonin is a free radical scavenger and...