Disruption of central nervous system barriers in multiple sclerosis

The delicate microenvironment of the central nervous system (CNS) is protected by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB). These barriers function in distinct CNS compartments and their anatomical basis lay on the junctional proteins present in endothelial cells for the BBB and in the choroidal epithelium for the BCB. During neuroinflammatory conditions like multiple sclerosis (MS) and its murine model...