Diabetes, Renal and Cardiovascular Disease in p47 phox−/− Chronic Granulomatous Disease

Chronic granulomatous disease is a rare immunodeficiency due to defects in the phagocyte NADPH oxidase. The X-linked form (gp91 phox deficiency) accounts for about 70 % of cases; autosomal recessive p47 phox deficiency accounts for about 25 % of cases. We identified a 10 % incidence of diabetes in p47 phox deficient CGD, but none in X-linked CGD. Renal and cardiovascular diseases were also higher in p47 phox deficiency. p47 phox deficient CGD...