Abstract P1-07-02: Significance of RB-ZEB axis in EMT phenotype of breast cancer and inhibition of ZEB by CDK4/6 inhibitor

The retinoblastoma protein (pRB) is a key tumor suppressor that regulates the progression of cell cycles from G1 to S phase. pRB is often inactivated due to mutation, very low level expression or hyperphosphorylation by cyclin-dependent kinases (CDKs) in many cancers. We found that knockdown of pRB induced the expression of ZEB1 (zinc finger E-box binding homeobox 1), which is one of the transcriptional repressors of the E-cadherin gene, and led...