Biodegradable elastomeric scaffolds for soft tissue engineering

Elastomeric copolymers of 1,3-trimethylene carbonate (TMC) and epsilon-caprolactone (CL) and copolymers of TMC and D,L-lactide (DLLA) have been evaluated as candidate materials for the preparation of biodegradable scaffolds for soft tissue engineering. TMC-DLLA copolymers are amorphous and degrade more rapidly in phosphate-buffered saline (PBS) of pH 7.4 at 37 degrees C than (semi-crystalline) TMC-CL copolymers. TMC-DLLA with 20 or 50 mol% TMC...