Arsenic trioxide impairs spermatogenesis via reducing gene expression levels in testosterone synthesis pathway.

Volume: 21, Issue: 8, Pages: 1562 - 1569
Published: Jul 17, 2008
Abstract
Arsenic trioxide (As2O3) has recently received a great deal of attention because of its capacity to cause complete remission of acute promyelocytic leukemia (APL). To evaluate possible toxicity on the male reproductive system during arsenic therapy, male mice were used as a model. Outbred mice (ICR/CD1 and S-W, 6 weeks old) were subcutaneously administered As2O3 continuously for 5 days, with a 2-day interval, for a period of 3 weeks. As2O3 doses...
Paper Details
Title
Arsenic trioxide impairs spermatogenesis via reducing gene expression levels in testosterone synthesis pathway.
Published Date
Jul 17, 2008
Volume
21
Issue
8
Pages
1562 - 1569
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