IL‐27‐Mediated Activation of Natural Killer Cells and Inflammation Produced Antitumour Effects for Human Oesophageal Carcinoma Cells

Interleukin (IL)‐27, composed of p28 and EBV‐induced gene 3 subunits, has diverse functions in enhancing cell‐mediated immunity and silencing the immunity. We examined whether forced expression of the p28‐linked EBI3 gene in human oesophageal carcinoma cells (Eca109) produced antitumour effects in a T cell‐defective condition. Tumour growth of Eca109 cells expressing IL‐27 (Eca109/IL‐27) was retarded in nude mice compared with parental and...