Original paper
Long Residence Time Inhibition of EZH2 in Activated Polycomb Repressive Complex 2
Abstract
EZH2/PRC2 catalyzes transcriptionally repressive methylation at lysine 27 of histone H3 and has been associated with numerous cancer types. Point mutations in EZH2 at Tyr641 and Ala677 identified in non-Hodgkin lymphomas alter substrate specificity and result in increased trimethylation at histone H3K27. Interestingly, EZH2/PRC2 is activated by binding H3K27me3 marks on histones, and this activation is proposed as a mechanism for...
Paper Details
Title
Long Residence Time Inhibition of EZH2 in Activated Polycomb Repressive Complex 2
Published Date
Dec 31, 2013
Journal
Volume
9
Issue
3
Pages
622 - 629
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Notes
History