The clinical impact of integrated FDG PET–CT on management decisions in patients with lung cancer

Published on Jun 1, 2009in Lung Cancer4.702
· DOI :10.1016/J.LUNGCAN.2008.09.006
N. Subedi1
Estimated H-index: 1
(Leeds Teaching Hospitals NHS Trust),
Andrew Scarsbrook29
Estimated H-index: 29
(Leeds Teaching Hospitals NHS Trust)
+ 3 AuthorsM. F. Muers1
Estimated H-index: 1
(Leeds Teaching Hospitals NHS Trust)
Sources
Abstract
Summary Purpose To retrospectively evaluate the clinical impact of FDG PET–CT on the management pathway of patients with lung cancer. Patients and methods One hundred and sixty-one patients with suspected lung cancer undergoing FDG PET–CT during the study period were analyzed. Before PET–CT, lung cancer MDT recorded scan indication, conventional clinical stage, and proposed treatment plan. The accuracy of integrated PET–CT compared with stand alone CT in preoperative staging of lung cancer was evaluated with pathological staging used as the reference standard. The effect of PET–CT on the subsequent management of patients was also evaluated. Results The agreement between CT and integrated PET–CT in preoperative staging of lung cancer was significant (p  Conclusion Addition of PET–CT to comprehensive evaluation of lung cancer can have significant clinical impact. There is marked improvement in staging the disease. Patients were frequently spared unnecessary treatment, and management was more appropriately targeted. PET permits reduction in the number of thoracotomies performed for non-resectable disease with predicted reduction in the morbidity rate and cost associated with unnecessary interventions.
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