Effect of Hemodialysis on Retinal Thickness in Patients with Diabetic Retinopathy, with and without Macular Edema, Using Optical Coherence Tomography

Published on Sep 15, 2014in Journal of Ophthalmology1.447
· DOI :10.1155/2014/709862
Nur Azem1
Estimated H-index: 1
(Tel Aviv Sourasky Medical Center),
Oriel Spierer12
Estimated H-index: 12
(Tel Aviv Sourasky Medical Center)
+ 1 AuthorsMeira Neudorfer17
Estimated H-index: 17
(Tel Aviv Sourasky Medical Center)
Sources
Abstract
Background. Effects of hemodialysis (HD) treatment on retinal thickness and macular edema are unclear. Objective. To evaluate changes in retinal thickness using optical coherence tomography (OCT) in end stage renal disease (ESRD) patients with diabetic retinopathy (DR), with and without diabetic macular edema (DME), undergoing HD. Methods. Nonrandomized prospective study. Forty eyes of DR patients with ESRD treated with HD were divided into two groups: patients with macular edema and patients without macular edema. Both eyes were analyzed. Patients underwent an ophthalmic examination including OCT measurements of retinal thickness, blood albumin and hemoglobin A1C levels, blood pressure, and body weight, 30 minutes before and after HD. Results. We found no significant effects of HD on retinal thickness among patients both with and without DME. The former showed a trend towards reduction in retinal thickness in foveal area following HD, while the latter showed an increase. There was no correlation between retinal thickness and mean blood pressure, weight, kinetic model value—, glycemic hemoglobin, or albumin levels before and after HD. Conclusions. HD has no significant effect on retinal thickness among patients with or without DME. Further studies on larger cohorts and repeated OCT examinations are needed to confirm the preliminary findings in this study.
📖 Papers frequently viewed together
13 Citations
7 Citations
References16
Newest
#1Sung Jae Yang (UOU: University of Ulsan)H-Index: 1
#2Yang Hee Han (UOU: University of Ulsan)H-Index: 1
Last. Sae Woon Sohn (UOU: University of Ulsan)H-Index: 1
view all 5 authors...
Background The aim was to evaluate changes in choroidal thickness, intraocular pressure (IOP) and other parameters of optical coherence tomography, such as central foveal thickness (CFT), macular volume, peripapillary retinal nerve fibre layer (RNFL) thickness after haemodialysis (HD). Methods Thirty-four eyes of 34 chronic renal failure patients (9 eyes with diabetic patients) who underwent haemodialysis in the Dialysis Unit of Gangneung Asan Hospital were included. CFT, macular volume, peripap...
29 CitationsSource
#1Fatih Ulaş (Abant Izzet Baysal University)H-Index: 8
#2Umit Dogan (Abant Izzet Baysal University)H-Index: 6
Last. Serdal Çelebi (Abant Izzet Baysal University)H-Index: 10
view all 6 authors...
The aim of this study is to evaluate the effects of haemodialysis with a high ultrafiltration rate on the choroidal and retinal thickness of non-diabetic end-stage chronic renal failure (CRF) patients using optical coherence tomography (OCT). Twenty-one eyes of 21 male CRF patients aged between 46 and 80 years were included in this prospective study. Retinal and choroidal thicknesses of the patients were measured using high-resolution OCT line scans with the activated enhanced depth imaging mode...
31 CitationsSource
#1Panagiotis Theodossiadis (UoA: National and Kapodistrian University of Athens)H-Index: 28
Last. Demetrios VlahakosH-Index: 22
view all 8 authors...
Background/Aims: To evaluate changes in macular thickness measured by optical coherence tomography (OCT) during a hemodialysis (HD) session in diabetic patients with end-stage renal
29 CitationsSource
#1Ingrid Auyanet (Hospital Universitario Insular de Gran Canaria)H-Index: 4
#2L.J. Rodríguez (Hospital Universitario Insular de Gran Canaria)H-Index: 2
Last. Checa (Hospital Universitario Insular de Gran Canaria)H-Index: 3
view all 8 authors...
Antecedentes: Diversos estudios han demostrado la eficacia de la hemodialisis (HD) sobre el edema macular de los pacientes diabeticos. Objetivo: Estudiar los efectos de una sesion de HD sobre el grosor foveolar, mediante tomografia de coherencia optica (OCT), en pacientes adultos con diabetes mellitus tipo 2 con insuficiencia renal cronica (IRC) estadio 5 secundaria a nefropatia diabetica en HD. Pacientes y metodos: Se estudiaron 25 ojos de 14 pacientes a los cuales se les realizo analitica y OC...
16 CitationsSource
#1Helmut MannH-Index: 1
Last. S. StillerH-Index: 5
view all 3 authors...
: Since the beginning of maintenance haemodialysis many attempts have been made to quantify this kind of renal replacement therapy. The most widely used methods are urea kinetic models and simple approximation formulae based on measured data of the individual patients. The most common term of dialysis dose is Kt/V. The errors of data put into the calculations are transferred to the result. Analysis of the error of the calculated result depending on the errors of the primary data using Gauss' law...
2 Citations
#1Dušica PahorH-Index: 8
#2B. GračnerH-Index: 7
Last. R HojsH-Index: 1
view all 4 authors...
BACKGROUND: The aim of the present prospective study was to compare retinal thickness between normal healthy subjects and chronic renal failure patients treated with maintenance hemodialysis (HD) as well as to determine whether there was any correlation between age and duration of HD treatment. PATIENTS AND METHODS: A total of 24 eyes of 12 HD patients and 32 eyes of 16 controls underwent optical coherence tomographic scanning (OCT) in the central disc of 6000 μm in diameter. RESULTS: The mean r...
13 CitationsSource
�������������������������������������������������������������������������������������������� We report herein the disappearance of macular hard exudates after the introduction of hemodialysis in diabetic patients. A 62‑year‑old woman and a 52‑year‑old man with diabetes mellitus showed hard exudates in the macula of the left eyes. Both patients had previously undergone panretinal photoco‑ agulation in both eyes. During the follow‑up hemodialysis was introduced for deteriorating chronic renal fail...
15 CitationsSource
#1Thomas A. CiullaH-Index: 53
#1Thomas A. CiullaH-Index: 7
Last. Bernard ZinmanH-Index: 103
view all 3 authors...
Diabetic retinopathy (DR) and diabetic macular edema (DME) are leading causes of blindness in the working-age population of most developed countries. The increasing number of individuals with diabetes worldwide suggests that DR and DME will continue to be major contributors to vision loss and associated functional impairment for years to come. Early detection of retinopathy in individuals with diabetes is critical in preventing visual loss, but current methods of screening fail to identify a siz...
923 CitationsSource
Purpose The aim of the present study was to compare retinal light sensitivity between normal healthy subjects and chronic renal failure patients treated with maintenance haemodialysis (HD), as well as to determine whether there is a correlation between visual field loss and the age of HD patients, duration of HD treatment and hypertensive retinopathy in HD patients. Methods A total of 50 eyes of 25 HD patients (16 male, nine female) and 30 eyes of 15 controls underwent visual field testing on th...
10 CitationsSource
#1Aysel Pelit (KSU: Kent State University)H-Index: 1
#1Aysel Pelit (KSU: Kent State University)H-Index: 13
Last. Yonca A. Akova (KSU: Kent State University)H-Index: 30
view all 3 authors...
Purpose. To investigate the visual field with FASTPAC 30-2 program before and after hemodialysis in patients with end stage renal disease. Materials and methods. Twenty eyes of 20 patients on regular hemodialysis were included in the study group. Twenty eyes of 20 healthy patients were chosen as control group. Intraocular pressures (IOP) were measured one hour before and one hour after the same hemodialysis session, and visual field was tested at the same times. Results. When IOP was compared be...
19 CitationsSource
Cited By11
Newest
#1Kshitiz KumarH-Index: 5
#1Kshitiz KumarH-Index: 17
Last. Amar AgarwalH-Index: 17
view all 4 authors...
Introduction Ocular fluid dynamics are known to improve during hemodialysis, and the improvement of uremia after dialysis may lead to osmotic pressure changes in the retina, which eventually affect retinal edema. Recent studies using optical coherence tomography (OCT) to assess the effect of hemodialysis on macular thickness have shown variable results with a majority of them finding a decrease in retinal thickness. Paradoxical neurosensory retinal detachment (NSD) may be defined as the accumula...
Source
BACKGROUND: The purpose of this study was to investigate the frequency of ocular manifestations in hemodialysis (HD) patients and short-term changes in ophthalmologic findings. METHOD: A total of 142 eyes of 71 HD patients were included in this study. Patients with corneal and conjunctival deposits, diabetic retinopathy, hypertensive retinopathy, cataract, optic atrophy or glaucoma were recorded. Schirmer I tests and The tear break up time (TBUT) were performed in the listed order to evaluate dr...
Source
#1Wei Fan (Third Military Medical University)H-Index: 2
#2Rong-Di Yuan (Third Military Medical University)H-Index: 1
Source
#1Idit Maharshak (Wolfson Medical Center)H-Index: 7
#2Idan HechtH-Index: 7
Last. Leonid Feldman (TAU: Tel Aviv University)H-Index: 11
view all 11 authors...
PURPOSE The aim of this study was to employ newly developed advanced image analysis software to evaluate changes in retinal layer thickness following hemodialysis. METHODS A non-randomized prospective study of patients with end-stage renal disease assessed on the same day before and after hemodialysis. Intraocular pressure and central corneal thickness were analyzed, and spectral domain optical coherence tomography results were automatically segmented using the Orion software and then compared. ...
Source
#1Hideyuki Nakano (Niigata University)
#2Hiruma Hasebe (Niigata University)H-Index: 8
Last. Takeo Fukuchi (Niigata University)H-Index: 26
view all 7 authors...
We aimed to evaluate choroid structural changes using swept-source optical coherence tomography (SS-OCT) following hemodialysis initiation in diabetic and nondiabetic patients with end-stage kidney disease (ESKD). In this multicenter, prospective, cross-sectional study, diabetic (DM group; 30 eyes; 16 patients) and nondiabetic patients (NDM group; 30 eyes; 15 patients) with ESKD were evaluated after hemodialysis initiation. SS-OCT findings were analyzed using a manual delineation technique and b...
Source
#1Yoshihiro Takamura (University of Fukui)H-Index: 18
#2Takehiro Matsumura (University of Fukui)H-Index: 12
Last. Masaru Inatani (University of Fukui)H-Index: 26
view all 15 authors...
Diabetic nephropathy and retinopathy (DR) including diabetic macular edema (DME) are representative microvascular complications of diabetes. We conducted a retrospective multicenter study analyzing records from patients with DR (132 eyes in 70 patients) and end-stage renal diseases (ESRD) who underwent hemodialysis for the first time. We demonstrated that the central retinal thickness (CRT) values were significantly decreased (p < 0.0001), and the best-corrected visual acuity (BCVA) values were ...
1 CitationsSource
#1David Montero (Libin Cardiovascular Institute of Alberta)H-Index: 20
#2Thomas Haider (UZH: University of Zurich)H-Index: 11
Last. Andreas J. Flammer (UZH: University of Zurich)H-Index: 35
view all 9 authors...
Abstract Background Vascular dysfunction is considered to spur the progression of cardiovascular disease in hemodialysis (HD) patients. Whether the HD procedure itself contributes to vascular dysfunction remains incompletely investigated. The present study sought to comprehensively assess the effects of HD on arterial and venous function along with concomitant changes in blood volume (BV). Methods and results We determined BV with high-precision, automated carbon monoxide-rebreathing, arterial s...
Source
#1Yoo-Ri Chung (Ajou University)H-Index: 9
#2Young Ho Kim (Ajou University)H-Index: 6
Last. Kihwang Lee (Ajou University)H-Index: 12
view all 5 authors...
Source
#1Jun Hyun Lim (Kosin University)H-Index: 1
#2Chang Zoo Kim (Kosin University)H-Index: 1
Last. Sang Joon Lee (Kosin University)H-Index: 11
view all 4 authors...
Source
#1Yong Un ShinH-Index: 11
#2Sang Eun LeeH-Index: 1
Last. Heeyoon ChoH-Index: 9
view all 6 authors...
AbstractTo evaluate the effect of hemodialysis on choroidal thickness and the choroidal vascularity index (CVI) in patients with end-stage renal disease (ESRD) by using swept-source optical coherence tomography.Thirty-two eyes of 32 patients with ESRD undergoing hemodialysis were recruited prospecti
5 CitationsSource