Letrozole increases ovarian growth and Cyp17a1 gene expression in the rat ovary

To evaluate the effects of letrozole on ovarian size and steroidogenesis in vivo, as well as on proliferation and steroidogenesis of theca-interstitial cells alone and in coculture with granulosa cells using an in vitro model.In vivo and in vitro studies.Research laboratory.Immature Sprague-Dawley female rats.In vivo effects of letrozole were studied in intact rats receiving either letrozole (90-day continuous-release SC pellets, 400 μg/d) or...