Advanced Therapeutic Dressings for Effective Wound Healing—A Review

Published on Nov 1, 2015in Journal of Pharmaceutical Sciences2.997
· DOI :10.1002/JPS.24610
Joshua S. Boateng27
Estimated H-index: 27
(University of Greenwich),
Ovidio Catanzano11
Estimated H-index: 11
(University of Greenwich)
Advanced therapeutic dressings that take active part in wound healing to achieve rapid and complete healing of chronic wounds is of current research interest. There is a desire for novel strategies to achieve expeditious wound healing because of the enormous financial burden worldwide. This paper reviews the current state of wound healing and wound management products, with emphasis on the demand for more advanced forms of wound therapy and some of the current challenges and driving forces behind this demand. The paper reviews information mainly from peer-reviewed literature and other publicly available sources such as the US FDA. A major focus is the treatment of chronic wounds including amputations, diabetic and leg ulcers, pressure sores, and surgical and traumatic wounds (e.g., accidents and burns) where patient immunity is low and the risk of infections and complications are high. The main dressings include medicated moist dressings, tissue-engineered substitutes, biomaterials-based biological dressings, biological and naturally derived dressings, medicated sutures, and various combinations of the above classes. Finally, the review briefly discusses possible prospects of advanced wound healing including some of the emerging physical approaches such as hyperbaric oxygen, negative pressure wound therapy and laser wound healing, in routine clinical care.
Figures & Tables
📖 Papers frequently viewed together
2,017 Citations
1,073 Citations
1,869 Citations
#1Fabienne Hartmann-Fritsch (Boston Children's Hospital)H-Index: 10
#2Thomas Biedermann (Boston Children's Hospital)H-Index: 25
Last. Ernst Reichmann (Boston Children's Hospital)H-Index: 23
view all 11 authors...
Extensive full-thickness skin loss, associated with deep burns or other traumata, represents a major clinical problem that is far from being solved. A promising approach to treat large skin defects is the use of tissue-engineered full-thickness skin analogues with nearly normal anatomy and function. In addition to excellent biological properties, such skin substitutes should exhibit optimal structural and mechanical features. This study aimed to test novel dermo-epidermal skin substitutes based ...
22 CitationsSource
#1Ovidio Catanzano (University of Naples Federico II)H-Index: 11
#2Vittoria D'Esposito (University of Naples Federico II)H-Index: 21
Last. Fabiana Quaglia (University of Naples Federico II)H-Index: 39
view all 13 authors...
Abstract In this paper we propose polysaccharide hydrogels combining alginate (ALG) and hyaluronan (HA) as biofunctional platform for dermal wound repair. Hydrogels produced by internal gelation were homogeneous and easy to handle. Rheological evaluation of gelation kinetics of ALG/HA mixtures at different ratios allowed understanding the HA effect on ALG cross-linking process. Disk-shaped hydrogels, at different ALG/HA ratio, were characterized for morphology, homogeneity and mechanical propert...
63 CitationsSource
#1A. Gomes (UBI: University of Beira Interior)H-Index: 25
#1Agostinho Gomes (UBI: University of Beira Interior)H-Index: 176
Last. Isabel C. Gouveia (UBI: University of Beira Interior)H-Index: 11
view all 4 authors...
The authors would like to thank Fundacao para a Ciencia e Tecnologia (FCT) for the funding granted concerning the project - PTDC/EBB-BIO/113671/2009 Skin2Tex. Also we would like to thank Fundo Europeu de Desenvolvimento Regional (FEDER) through (FCOMP-01-0124-FEDER-014752) COMPETE - Programa Operacional Factores de Competitividade (POFC) for the co-funding.
52 CitationsSource
#1Pascal Morissette Martin (Laval University)H-Index: 2
#2Amandine Maux (Laval University)H-Index: 2
Last. Julie Fradette (Laval University)H-Index: 20
view all 7 authors...
Promotion of skin repair for acute or chronic wounds through the use of tissue-engineered products is an active field of research. This study evaluates the effects mediated by tissue-engineered biological dressings containing human in vitro-differentiated adipocytes and adipose-derived stromal cells (ASCs). Re-epithelialization, granulation tissue formation and neovascularization of full-thickness cutaneous wounds were specifically assessed using a murine model featuring a fluorescent epidermis....
24 CitationsSource
#1E.L. Gee Kee (Children's Medical Research Institute)H-Index: 3
#2Roy M. Kimble (Children's Medical Research Institute)H-Index: 39
Last. Kellie Stockton (Children's Medical Research Institute)H-Index: 15
view all 5 authors...
Abstract Background This study compared the effects of three silver dressing combinations on small to medium size acute partial thickness burns in children, focusing on re-epithelialization time, pain and distress during dressing changes. Method Children (0–15 years) with clean, ≤10% total body surface area (TBSA) partial thickness burns who met the inclusion criteria were included in the study. Children received either (1) Acticoat™; (2) Acticoat™ with Mepitel™; or (3) Mepilex Ag™ dressings. Me...
42 CitationsSource
#1Joshua S. Boateng (University of Greenwich)H-Index: 27
#2Rocio Burgos-Amador (University of Greenwich)H-Index: 1
Last. Harshavardhan Pawar (University of Greenwich)H-Index: 8
view all 4 authors...
Lyophilized wafers comprising sodium alginate (SA) and gelatin (GE) (0/100, 75/25, 50/50, 25/75, 0/100 SA/GE, respectively) with silver sulfadiazine (SSD, 0.1% w/w) have been developed for potential application on infected chronic wounds. Polymer–drug interactions and physical form were characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD), respectively, while morphological structure was examined using scanning electron microscopy (SEM). Functional character...
73 CitationsSource
#1Di Zhang (Jiangnan University)H-Index: 72
#1Di Zhang (Jiangnan University)H-Index: 99
Last. Jun Wang (Anda: Anhui University)H-Index: 16
view all 7 authors...
Abstract The objective of this study was to develop a novel carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing. To prepare the crosslinked hydrogels, poly(vinyl alcohol) (PVA) was grafted with succinate acid to yield carboxyl-modified poly(vinyl alcohol) (PVA-COOH). Hydrogel films based on PVA-COOH and chitosan (CS) at different concentrations were crosslinked through the formation of amide linkages. The mechanical properties of these crosslink...
135 CitationsSource
#1Zoriah Binti Aziz (UM: University of Malaya)H-Index: 13
#2Nicky Cullum (University of Manchester)H-Index: 64
There is no high quality evidence that electromagnetic therapy increases the rate of healing of venous leg ulcers, and further research is needed.
64 CitationsSource
#1Akira AokiH-Index: 36
#2Koji MizutaniH-Index: 16
Last. Yuichi IzumiH-Index: 54
view all 16 authors...
Laser irradiation has numerous favorable characteristics, such as ablation or vaporization, hemostasis, biostimulation (photobiomodulation) and microbial inhibition and destruction, which induce various beneficial therapeutic effects and biological responses. Therefore, the use of lasers is considered effective and suitable for treating a variety of inflammatory and infectious oral conditions. The CO2 , neodymium-doped yttrium-aluminium-garnet (Nd:YAG) and diode lasers have mainly been used for ...
115 CitationsSource
#1Elena Llorens (UPC: Polytechnic University of Catalonia)H-Index: 8
#2Silvia Calderón (UPC: Polytechnic University of Catalonia)H-Index: 1
Last. Jordi Puiggalí (UPC: Polytechnic University of Catalonia)H-Index: 39
view all 4 authors...
Abstract Polyhexamethylenebiguanide hydrochloride (PHMB), a low molecular weight polymer related to chlorohexidine (CHX), is a well-known antibacterial agent. In this study, polylactide (PLA) nanofibers loaded with PHMB were produced by electrospinning to obtain 3D biodegradable scaffolds with antibacterial properties. PLA fibers loaded with CHX were used as control. The electrospun fibers were studied and analyzed by SEM, FTIR, DSC and contact angle measurements. PHMB and CHX release from loade...
45 CitationsSource
Cited By315
#1Yuna Qian (CAS: Chinese Academy of Sciences)H-Index: 12
#2Chuchu Xu (CAS: Chinese Academy of Sciences)
Last. Jianliang Shen (CAS: Chinese Academy of Sciences)H-Index: 24
view all 9 authors...
Abstract Limited therapeutic options are available for healing chronic non-self-healing diabetic wounds, which are characterized by bacterial infection as well as a hypoxic microenvironment. Here, we report a simple and efficient strategy to generate a multifunctional organic-inorganic hybrid hydrogel to simultaneously overcome these problems. This hybrid hydrogel is composed of a dual cross-linked silk fibroin (SF) network with hemoglobin (Hb) and gallium (Ga) (referred to as SF/Hb/Ga). Materia...
#1Salar KhaledianH-Index: 4
#2Danial KahriziH-Index: 15
Last. Fleming MartínezH-Index: 46
view all 6 authors...
Abstract In this study, polymeric composite nanofiber consisting of polyvinyl alcohol (PVA)/gum tragacanth (GT)/molybdenum disulfide (MoS2) were successfully developed via electrospinning process for tetracycline (TCH) delivery. Experimental analysis including UV–vis and XRD indicated that the MoS2 nanosheets were exfoliated. Based on the SEM analysis the prepared nanofiber has a smooth surface with a size diameter below 100 nm. The existence of MoS2 nanosheets in the composite nanofibers signif...
#1Meiping Tian (Ocean University of China)H-Index: 6
#2Andi Zhang (Ocean University of China)H-Index: 1
Last. Ya Liu (Ocean University of China)H-Index: 21
view all 5 authors...
Abstract Hydrogels have gained great attentions as wound dressing. Binding to the tissue and preventing wound infection were the basic requirements for an “ideal dressing”. We employed L-DOPA and e-Poly-L-lysine to modify thermo-sensitive hydroxybutyl chitosan (HBC) to obtain (L-DOPA) - (e-Poly-L-lysine)-HBC hydrogels (eLHBC). The eLHBC exhibited an almost 1.5 fold (P
#1Nan Yang (Nanjing Tech University)H-Index: 8
#2Heng Guo (Southern University of Science and Technology)H-Index: 9
Last. Xiaochen Dong (Nanjing Tech University)H-Index: 71
view all 10 authors...
Abstract Subcutaneous abscesses caused by drug-resistant bacteria pose huge challenges to human health. The design of infection microenvironment-activated biomaterials has an advantage for the diagnosis and treatment of infective diseases due to its high specificity and efficiency. Herein, a novel theranostic platform based on Cu2O nanoparticles (NPs) is successfully constructed via a simple, fast and low-cost approach. The Cu2O NPs exhibit high sensitivity to overexpressed H2S and H2O2 in the b...
#1Forough Hemmatgir (IAU: Islamic Azad University)
#2Narjes Koupaei (IAU: Islamic Azad University)H-Index: 2
Last. Elahe Poorazizi (IAU: Islamic Azad University)H-Index: 5
view all 3 authors...
Abstract In this research, a novel semi-interpenetrating hydrogel network comprising of polyethylene glycol diacrylate (PEGDA)/polyvinyl alcohol (PVA)/tragacanth gum (TG) with adaptable mechanical, biological, and physical characteristics was fabricated for wound healing purposes. The chemical structure of the films and the surface morphology were examined by FTIR and SEM, respectively. In addition, swelling ratio, mechanical characteristics, water vapor transmission rate (WVTR), gel fraction, a...
#1Ayça Bal-OzturkH-Index: 2
#2Bengi ÖzkahramanH-Index: 9
Last. Emine Alarçin (Marmara University)H-Index: 8
view all 6 authors...
Wound repair is a complex process that has not been entirely understood. It can conclude in several irregularities. Hence, designing an appropriate wound dressing that can accelerate the healing period is critical. Infections, a major obstacle to wound repair, cause an elevated inflammatory responses and result in ultimate outcome of incomplete and prolonged wound repair. To overcome these shortcomings, there is a growing requirement for antibacterial wound dressings. Dressings with antibacteria...
#1Mahla Behyari (AUT: Amirkabir University of Technology)H-Index: 1
#2Rana Imani (AUT: Amirkabir University of Technology)H-Index: 13
Last. Hamid Keshvari (AUT: Amirkabir University of Technology)H-Index: 9
view all 3 authors...
Among wound care products, nanofibrous structure incorporating herbal ingredients with the potential of sustained and localized release are currently of great interest. In this study, the nano-niosomal formulation of an effective herbal ingredient, Ethanolic Extract of Propolis (EEP), is introduced in a silk fibroin (SF)-based nanofibrous mat via blend electrospinning and evaluated as a wound dressing. According to the results, the size and encapsulation efficacy of drug-loaded niosomes are 404....
#1Yan Peng (SWU: Southwest University)H-Index: 1
#2Yan Ma (SWU: Southwest University)H-Index: 2
Last. Zhi Li (SWU: Southwest University)H-Index: 10
view all 7 authors...
Abstract Combining biodegradable materials with natural plant components for wound dressing has been receiving significant attention. ART is a sesquiterpene lactone compound extracted from Artemisia annua L., possessing multiple pharmacological effects including antibacterial activity and anti-inflammatory property. Herein, the blended polylactic acid glycolic acid (PLGA)/silk fibroin (SF) membranes loaded with artemisinin (ART) are fabricated through electrospinning. With aid of SF, the fabrica...
#1Sara Torkaman (Iranian Research Organization for Science and Technology)H-Index: 1
#2Hossein Rahmani (Iranian Research Organization for Science and Technology)H-Index: 7
Last. Seyed Heydar Mahmoudi Najafi (Iranian Research Organization for Science and Technology)H-Index: 2
view all 4 authors...
Abstract Chitosan, a well-known biopolymer due to its unique properties, has received considerable attention as a result of the amine group activity that locates on the backbone of chitosan. To improve the mechanical and antibacterial characteristics of chitosan, various modifications have been used. Amino acids, the monomeric units of proteins, among all other compounds have been chosen to discuss as promising materials for wound healing in combination with chitosan. This review aims to provide...