Original paper
Transforming growth factor‐β released by apoptotic white blood cells during red blood cell storage promotes transfusion‐induced alloimmunomodulation
Abstract
BACKGROUND Red blood cell (RBC) alloimmunization is a major immunologic risk of transfusion. However, RBC storage facilitates white blood cell (WBC) apoptosis and apoptotic cells have immunomodulatory properties. We investigated the behavior of WBCs, and apoptosis in particular, in RBC units during storage and then studied the impact of WBC apoptosis on the modulation of posttransfusion alloimmunization in RBC products stored short term. STUDY...
Paper Details
Title
Transforming growth factor‐β released by apoptotic white blood cells during red blood cell storage promotes transfusion‐induced alloimmunomodulation
Published Date
Mar 21, 2015
Journal
Volume
55
Issue
7
Pages
1721 - 1735
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Notes
History