M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

Tumor associated macrophages (TAMs) are present in high density in solid tumors. TAMs share many characteristics with alternatively activated macrophages, also called M2. They have been shown to favor tumor development and a role in chemoresistance has also been suggested. Here, we investigated the effects of M2 in comparison to M1 macrophages on cancer cell sensitivity to etoposide.We set up a model of macrophage polarization, starting from...