Correction for partial volume effects in PET: principle and validation.

The accuracy of PET for measuring regional radiotracer concentrations in the human brain is limited by the finite resolution capability of the scanner and the resulting partial volume effects (PVEs). We designed a new algorithm to correct for PVEs by characterizing the geometric interaction between the PET system and the brain activity distribution.The partial volume correction (PVC) algorithm uses high-resolution volumetric MR images correlated...