Oestrogen Induces Rhythmic Expression of the Kisspeptin-1 Receptor GPR54 in Hypothalamic Gonadotrophin-Releasing Hormone-Secreting GT1-7 Cells

Oestrogen-stimulated preovulatory gonadotrophin surges are temporally regulated in a way that remains not fully understood. Mammalian ovulation requires surges of gonadotrophin-releasing hormone (GnRH), released from specialised neurones in the hypothalamus. Surge regulation is mediated by ovarian oestrogen (17β-oestradiol; E2) feedback-acting as a negative signal until the early afternoon of the pro-oestrous phase, at which point it stimulates...