Selection of non-steroidal anti-inflammatory drug and treatment regimen for sulfur mustard-induced cutaneous lesions.

Published on Jul 2, 2016in Cutaneous and Ocular Toxicology1.82
· DOI :10.3109/15569527.2015.1076436
Jennifer L. Plahovinsak3
Estimated H-index: 3
(Battelle Memorial Institute),
Matthew Buccellato2
Estimated H-index: 2
(Battelle Memorial Institute)
+ 1 AuthorsJohn S. Graham18
Estimated H-index: 18
(United States Army Medical Research Institute of Chemical Defense)
Sources
Abstract
AbstractThe inflammatory process plays an important role in sulfur mustard (HD) injury and HD pathogenesis, suggesting that anti-inflammatory treatments applied as soon as possible following HD injury may reduce tissue damage and accelerate healing. This study used the HD dermal weanling swine model to investigate the efficacy of two non-steroidal anti-inflammatory drugs, capsaicin and diclofenac, when applied in combination with the steroid, clobetasol. The therapeutic regimen was also investigated with respect to initiation of treatment post-exposure, frequency and duration. Yorkshire-cross pigs were randomly assigned to experimental groups, corresponding to all combinations of treatment (capsaicin with clobetasol or diclofenac with clobetasol), onset time (1, 2 or 4 h post-exposure), treatment duration (1, 3 or 5 days) and frequency of applications (2, 3 or 4 per day). For each animal, two sites on the ventral abdomen were exposed to 400 μL of neat HD for 8 min to achieve superficial dermal (SD) lesion...
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References38
Newest
#1Stéphane MouretH-Index: 15
#2Julien WartelleH-Index: 5
Last. Isabelle BoudryH-Index: 9
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Sulfur mustard (SM) is a strong bifunctional alkylating agent that produces severe tissue injuries characterized by erythema, edema, subepidermal blisters and a delayed inflammatory response after cutaneous exposure. However, despite its long history, SM remains a threat because of the lack of effective medical countermeasures as the molecular mechanisms of these events remain unclear. This limited number of therapeutic options results in part of an absence of appropriate animal models. We propo...
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#1Sherri C. Young (Lehigh University)H-Index: 7
#2Karine Fabio (Lehigh University)H-Index: 6
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 71
view all 11 authors...
As part of a continuous effort to develop efficient counter measures against sulfur mustard injuries, several unique NSAID prodrugs have been developed and screened for anti-inflammatory properties. Presented herein are three classes of prodrugs which dually target inflammation and cholinergic dysfunction. Compounds 1-28 contain common NSAIDs linked either to choline bioisosteres or to structural analogs of acetylcholinesterase (AChE) inhibitors. These agents have shown utility as anti-vesicants...
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#1Ian P. Dick (ICI: Imperial Chemical Industries)H-Index: 2
#2Robert C. Scott (ICI: Imperial Chemical Industries)H-Index: 11
Abstract— Pig skin has been shown to have similar histological and physiological properties to human skin and has been suggested as a good model for human skin permeability. In this series of experiments, the in-vitro permeability of pig ear skin was compared with human (abdominal) skin and rat (dorsal) skin using both hydrophilic (water, mannitol, paraquat) and lipophilic (aldrin, carbaryl, fluazifop-butyl) penetrants. Pig skin was found to have a closer permeability character than rat skin to ...
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AbstractBackground:Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. However, extensive research ...
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#1Anna Zampetti (UCSC: Catholic University of the Sacred Heart)H-Index: 14
#2Claudio FelicianiH-Index: 33
Last. Pierluigi AmerioH-Index: 19
view all 4 authors...
Clobetasol-17 propionate is a dihalogenated corticosteroid which, on the basis of the vasoconstrictor assay, is classified as the most potent of all topical steroids. Since 1973 it has been marketed specifically for the short term topical treatment of moderate and severe cortico-responsive dermatoses for its antinflammatory, immunosuppressive and antimitotic effects. Psoriasis, atopic dermatitis, chronic eczema, boullous disorders and itching dermatosis of the genital area are usually well contr...
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#1Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
#2Maayan Cohen (Israel Institute for Biological Research)H-Index: 9
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
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Background/purpose: Skin exposure to sulfur mustard (HD) results in erythema, edema and severe injury, which take long time to heal and might impose a heavy burden on the health system. Despite many years of research, there is no treatment that prevents the development of the cytotoxic effects of HD causing acute and prolonged damage to the skin. Therefore, it is of great importance to develop treatments that will ameliorate the extent of injury and improve as well as shorten the healing process...
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#1Pierangelo Geppetti (UniFI: University of Florence)H-Index: 99
#2Romina Nassini (UniFI: University of Florence)H-Index: 36
Last. Silvia Benemei (UniFI: University of Florence)H-Index: 30
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Neurogenic inflammatory responses have recently been linked to both acute and chronic pathological conditions in the urinary tract. Neurogenic inflammation encompasses a series of vascular and non-vascular inflammatory responses, triggered by the activation of primary sensory neurons and the subsequent release of inflammatory neuropeptides, including substance P and calcitonin gene-related peptide. The reduction of neurogenic inflammatory responses may be key in the mode of action of the adrener...
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#1Frances M. Reid (Battelle Memorial Institute)H-Index: 9
#2Nancy A. Niemuth (Battelle Memorial Institute)H-Index: 13
Last. John S. GrahamH-Index: 18
view all 5 authors...
Background/purpose: A sulfur mustard (SM)-induced cutaneous injury model was developed in weanling swine to evaluate the efficacy of candidate treatment regimens. Lesions were assessed clinically and histopathologically. Histopathologic evaluation of lesions was a subjective and invasive assessment. Biomechanical engineering methods offer an objective and less invasive method to evaluate lesions. The purpose of this study was to use biomechanical engineering instruments to assess SM-induced lesi...
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#1John S. GrahamH-Index: 18
#2Robert P. ChilcottH-Index: 23
Last. Beverly I MalinerH-Index: 2
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Sulfur mustard is an alkylating chemical warfare agent that primarily affects the eyes, skin, and airways. Sulfur mustard injuries can take several months to heal, necessitate lengthy hospitalizations, and result in significant cosmetic and/or functional deficits. Historically, blister aspiration and/or deroofing (epidermal removal), physical debridement, irrigation, topical antibiotics, and sterile dressings have been the main courses of action in the medical management of cutaneous sulfur must...
#1James V. Rogers (Battelle Memorial Institute)H-Index: 16
#2Jonathon W. Kohne (Battelle Memorial Institute)H-Index: 2
Last. John S. GrahamH-Index: 18
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ABSTRACTSulfur mustard [bis(2-chloroethyl)sulfide, SM] is a chemical warfare agent that penetrates the skin and causes extensive blistering. A weanling swine model was previously developed to evaluate wound healing associated with SM-induced cutaneous injuries. This study was performed to characterize short-term liquid SM exposures using this weanling swine skin model by measuring SM recovery from dosing templates and associated components. Female Yorkshire crossbred swine were exposed cutaneous...
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#1Joanna A. Ruszkiewicz (University of Konstanz)H-Index: 2
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Abstract Sulfur mustard (SM) is a toxicant and chemical warfare agent with strong vesicant properties. The mechanisms behind SM-induced toxicity are not fully understood and no antidote or effective therapy against SM exists. Both, the risk of SM release in asymmetric conflicts or terrorist attacks and the usage of SM-derived nitrogen mustards as cancer chemotherapeutics, render the mechanisms of mustard-induced toxicity a highly relevant research subject. Herein, we review a central role of the...
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#1Leila Etemad (MUMS: Mashhad University of Medical Sciences)H-Index: 13
#2Mohammad Moshiri (MUMS: Mashhad University of Medical Sciences)H-Index: 9
Last. Mahdi Balali-Mood (Birjand University of Medical Sciences)H-Index: 5
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AbstractSulfur mustard (SM) is a blistering chemical warfare agent that was used during the World War I and in the Iraq–Iran conflict. The aim of this paper is to discuss and critically review the ...
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