The efficacy of fibrinogen concentrate compared with cryoprecipitate in major obstetric haemorrhage – an observational study

SUMMARY Background Fibrinogen replacement is critical in major obstetric haemorrhage ( MOH ). Purified, pasteurised fibrinogen concentrate appears to have benefit over cryoprecipitate in ease of administration and safety but is unlicensed in pregnancy. In July 2009, the Irish Blood Transfusion Service replaced cryoprecipitate with fibrinogen. Objectives To examine the impact of this externally imposed change on blood product use and clinical...