The efficacy of add-on tacrolimus for minor flare in patients with systemic lupus erythematosus: a retrospective study

We have assessed the effectiveness of tacrolimus for minor flares in systemic lupus erythematosus (SLE) patients.The medical records of 313 patients were retrospectively reviewed over a period of seven years, from 2006 to 2013. We enrolled patients with minor flare treated with add-on tacrolimus, without glucocorticoid (GC) intensification (tacrolimus group). Minor flare was defined as a ≥ 1-point increase in a total score between 3 and 11 in...