Aggrecan- and COMP-Loaded Poly-(Lactic-Co-Glycolic Acid) Nanoparticles Stimulate Chondrogenic Differentiation of Human Mesenchymal Stem Cells

During embryogenesis, specific proteins expressed in cells have key roles in the formation of differentiated cells and tissues. Delivery of specific proteins into specific cells, both in vitro and in vivo, has proved to be exceedingly difficult. In this study, we developed a safe and efficient protein delivery system using encapsulation of proteins into biodegradable poly-(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). The PLGA NPs were...