Adenosine receptor targets for pain
Abstract
The main focus for the development of adenosine targets as analgesics to date has been A1Rs due to its antinociceptive profile in various preclinical pain models. The usefulness of systemic A1R agonists may be limited by other effects (cardiovascular, motor), but enhanced selectivity for pain might occur with partial agonists, potent and highly selective agonists, or allosteric modulators. A2AR agonists exhibit some peripheral pronociceptive...
Paper Details
Title
Adenosine receptor targets for pain
Published Date
Dec 1, 2016
Journal
Volume
338
Pages
1 - 18
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