Original paper

Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect

Volume: 31, Issue: 4, Pages: 538 - 545
Published: May 28, 2015
Abstract
Tumor acidity represents a major cause of chemoresistance. Proton pump inhibitors (PPIs) can neutralize tumor acidity, sensitizing cancer cells to chemotherapy.To compare the anti-tumor efficacy of different PPIs in vitro and in vivo.In vitro experiments PPIs anti-tumor efficacy in terms of cell proliferation and cell death/apoptosis/necrosis evaluation were performed. In vivo PPIs efficacy experiments were carried out using melanoma xenograft...
Paper Details
Title
Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect
Published Date
May 28, 2015
Volume
31
Issue
4
Pages
538 - 545
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