Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect

Tumor acidity represents a major cause of chemoresistance. Proton pump inhibitors (PPIs) can neutralize tumor acidity, sensitizing cancer cells to chemotherapy.To compare the anti-tumor efficacy of different PPIs in vitro and in vivo.In vitro experiments PPIs anti-tumor efficacy in terms of cell proliferation and cell death/apoptosis/necrosis evaluation were performed. In vivo PPIs efficacy experiments were carried out using melanoma xenograft...