Relationships between dose to the gastro-intestinal tract and patient-reported symptom domains after radiotherapy for localized prostate cancer

Published on Sep 4, 2015in Acta Oncologica3.701
· DOI :10.3109/0284186X.2015.1063779
Maria Thor16
Estimated H-index: 16
(MSK: Memorial Sloan Kettering Cancer Center),
Caroline Olsson12
Estimated H-index: 12
(University of Gothenburg)
+ 9 AuthorsJoseph O. Deasy63
Estimated H-index: 63
(MSK: Memorial Sloan Kettering Cancer Center)
ABSTRACTBackground. Gastrointestinal (GI) morbidity after radiotherapy (RT) for prostate cancer is typically addressed by studying specific single symptoms. The aim of this study was to explore the interplay between domains of patient- reported outcomes (PROs) on GI morbidity, and to what extent these are explained by RT dose to the GI tract.Material and methods. The study included men from two Scandinavian studies (N = 211/277) who had undergone primary external beam radiotherapy (EBRT) for localized prostate cancer to 70–78 Gy (2 Gy/fraction). Factor analysis was applied to previously identified PRO-based symptom domains from two study-specific questionnaires. Number of questions: 43; median time to follow-up: 3.6–6.4 years) and dose-response outcome variables were defined from these domains. Dose/volume parameters of the anal sphincter (AS) or the rectum were tested as predictors for each outcome variable using logistic regression with 10-fold cross-validation. Performance was assessed using area under...
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