The BioPlex Network: A Systematic Exploration of the Human Interactome
Abstract
Protein interactions form a network whose structure drives cellular function and whose organization informs biological inquiry. Using high-throughput affinity-purification mass spectrometry, we identify interacting partners for 2,594 human proteins in HEK293T cells. The resulting network (BioPlex) contains 23,744 interactions among 7,668 proteins with 86% previously undocumented. BioPlex accurately depicts known complexes, attaining 80%-100%...
Paper Details
Title
The BioPlex Network: A Systematic Exploration of the Human Interactome
Published Date
Jul 1, 2015
Journal
Volume
162
Issue
2
Pages
425 - 440
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