Cell‐specific integration of nuclear receptor function at the genome

Nuclear receptors ( NRs ) encompass a family of regulatory proteins that directly couple small‐molecule signaling to transcriptional regulation. Initial studies of specific NR targets led to a model in which NRs bind highly specific DNA motifs in proximal promoter regions and strongly induce gene transcription in response to ligand binding. More recently, genome‐wide studies have added to the complexity of this classic model of NR function. In...