Noninvasive imaging by optical coherence tomography to monitor retinal degeneration in the mouse.

Optical coherence tomography (OCT) is a high-resolution imaging technique that measures the intensity of backscattered light from biological microstructures in living tissue. The objective was to evaluate OCT as a routine, noninvasive technique for quantitative measurements of retinal thickness and detachment in small animal models of retinal degenerative diseases.An OCT scanning unit was designed and built to visualize retinal tissue from...