Physical Size Does Not Determine the Unique Histopathological Response Seen in the Injured Mouse Spinal Cord

Mice display a wound healing process after spinal cord injury that has not been seen in any other species. Rather than exhibiting progressive necrosis and cavitation at the injury site, the mouse lesion site fills in with connective tissue. The connective tissue matrix then undergoes a remodeling in which it contracts, drawing the two ends of the injured spinal cord closer together. One possible explanation for this unique wound healing response...