Original paper
M-opsin protein degradation is inhibited by MG-132 in Rpe65⁻/⁻ retinal explant culture.
Abstract
The 65 kDa retinal pigment epithelium-specific protein, RPE65, is an essential enzyme for 11-cis-retinal synthesis in the eye. Mutations of the RPE65 gene in humans result in severe vision loss, and Rpe65(-/-) mice show early cone photoreceptor degeneration. We used an explant culture system to evaluate whether posttranslational downregulation of M-opsin protein in Rpe65(-/-) mice is caused by proteolytic degradation.The eyes of three-week-old...
Paper Details
Title
M-opsin protein degradation is inhibited by MG-132 in Rpe65⁻/⁻ retinal explant culture.
Published Date
Jan 1, 2012
Journal
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Notes
History