Studies on the mechanism of action of cytoxan. Evidence of activation in vivo and in vitro.

Summary null The reported inactivity of Cytoxan, when assayed directly in mammalian cell cultures, has been confirmed, even with cell lines derived from experimental tumors which respond in vivo to Cytoxan therapy. null However, blood serum or crude liver extracts from rats treated with Cytoxan were inhibitory in vitro for serially propagated mammalian cells derived from normal or neoplastic tissue, as well as for cells in primary culture. null...