HER2-directed therapy for metastatic breast cancer.
Abstract
Human epidermal growth factor receptor 2 (HER2) overexpression drives the biology of 20% of breast cancers, and predicts a poor prognosis for patients. HER2-targeted therapies significantly improve outcomes for HER2-positive patients with both early and metastatic breast cancer. Currently three HER2-targeted agents, trastuzumab (Herceptin), lapatinib (Tykerb), and pertuzumab (Perjeta), are available for the treatment of HER2-positive metastatic...
Paper Details
Title
HER2-directed therapy for metastatic breast cancer.
Published Date
Mar 1, 2013
Journal
Volume
27
Issue
3
Pages
166 - 75
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Notes
History