Prostaglandins Leukotrienes and Essential Fatty Acids
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ABSTRACT null null Women with low n-3 (omega-3) status in pregnancy can reduce their risk of early preterm birth ( 0.85), while more moderate relationships were observed between measures in whole blood and RBC (R2 0.55 to 0.71), or plasma and RBC (R2 0.55 to 0.63). Using the conversion equations, established cut-points for low and replete n-3 status in whole blood ( 4.9% of total fatty acids) converted to null 4.3% of plasma total fatty acids, and to null 8.1% of RBC total fatty acids. Agreement...
#1Juhi Nema (Bharati Vidyapeeth University)H-Index: 2
#2Karuna Randhir (Bharati Vidyapeeth University)H-Index: 8
Last. Sadhana Joshi (Bharati Vidyapeeth University)H-Index: 34
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BACKGROUND Preeclampsia is a pregnancy disorder characterized with abnormal placental angiogenesis. Vitamin D and long chain polyunsaturated fatty acids (LCPUFA) play a crucial role in pregnancy and are required for normal placental and fetal growth and development. This study reports the effect of maternal vitamin D on LCPUFA levels in the mother and offspring brain fatty acid levels and angiogenic markers in a rat model of preeclampsia. METHODS Female rats were divided into four groups from pr...
#1Matthew Vander Ploeg (UNC: University of North Carolina at Chapel Hill)
#2Kevin Quinn (University of Colorado Denver)H-Index: 12
Last. Saame Raza Shaikh (UNC: University of North Carolina at Chapel Hill)H-Index: 36
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ABSTRACT null null Obesity drives an imbalanced signature of specialized pro-resolving mediators (SPM). Herein, we investigated if high fat diet-induced obesity dysregulates the concentration of SPM intermediates in the brains of C57BL/6J mice. Furthermore, given the benefits of EPA for cardiometabolic diseases, major depression, and cognition, we probed the effect of an EPA supplemented high fat diet on brain SPM intermediates. Mass spectrometry revealed no effect of the high fat diet on PUFA-d...
Fatty liver is a side effect of chemotherapy that limits the ability to treat colorectal cancer (CRC) patients in the most effective way. The aim of this study was to determine hepatic fatty acid composition and expression of genes involved in lipid metabolism at two time points following sequential chemotherapy treatment with Irinotecan (CPT-11)+5-fluorouracil (5-FU), agents commonly used to treat human colorectal cancer. Female Fischer 344 rats were provided a semi-purified AIN-76 basal diet w...
Abstract null null Vascular structure and integrity are at the forefront of blood pressure regulation. However, there are many factors that affect the responses of the vessels. One of these is the inflammatory processes associated with high cholesterol and its modification. 15-lipoxygenase (15-LOX) is the critical enzyme in cholesterol oxidation, but this enzyme is also responsible for the synthesis of specialized proresoving lipid mediators (SPMs) called Lipoxin (Lxs) and Resolvin (Rvs). In thi...
#1Claudio Gemperle (Boston Children's Hospital)H-Index: 7
#2Syndi Tran (Boston Children's Hospital)
Last. Martin Hersberger (UZH: University of Zurich)H-Index: 44
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Abstract null null Obesity leads to chronic inflammation of the adipose tissue which is tightly associated with the metabolic syndrome, type 2 diabetes and cardiovascular disease. Inflammation of the adipose tissue is mainly characterized by the presence of crown-like structures composed of inflammatory macrophages in the neighborhood of adipocytes. Resolvin D1 (RvD1), a potent anti-inflammatory and pro-resolving lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid, has been s...
#1Bo Liu (Inner Mongolia Agricultural University)H-Index: 9
#2Changqi Fu (Inner Mongolia Agricultural University)H-Index: 6
Last. Shuang Feng (Inner Mongolia Agricultural University)H-Index: 3
view all 8 authors...
Abstract null null It is known that prostaglandin E2 (PGE2) induces proliferation of epithelia in bovine endometrial explants, however, the detailed mechanism of regulation of PGE2 in inducing bovine endometrial epithelial cell (bEEC) proliferation is unclear. In this study, we determined whether proliferation of bEECs is promoted by PGE2-prostaglandin E receptor 2 (PTGER2) signaling activation through cell cycle regulation. The results demonstrated that bEECs proliferation was induced by treatm...
#1Mu-yuan Ma (HAU: Huazhong Agricultural University)
#2Ke-lei Li (Qingdao University)
Last. Ling Wang (HAU: Huazhong Agricultural University)
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BACKGROUND AND OBJECTIVES The relationship between omega-3 index and type 2 diabetes (T2D) is not well established. It is unclear if the change of omega-3 index will affect T2D. Aiming of the present systematic review was to elucidate the correlation between omega-3 index and T2D. METHODS AND STUDY DESIGN A comprehensive search on PubMed, EMBASE and Web of Science (from 1948 to May 2021) was conducted. The overall effect size (standard mean difference) was combined using a random-effect model. R...
#1Jakob Hamilton (UNC: University of North Carolina at Chapel Hill)
#2Eric L. Klett (UNC: University of North Carolina at Chapel Hill)H-Index: 18
The consumption of linoleic acid (LA, ω-6 18:2), the most common ω-6 polyunsaturated fatty acid (PUFA) in the Modern Western diet (MWD), has significantly increased over the last century in tandem with unprecedented incidence of chronic metabolic diseases like obesity and type 2 diabetes mellitus (T2DM). Although an essential fatty acid for health, LA was a very rare fatty acid in the diet of humans during their evolution. While the intake of other dietary macronutrients (carbohydrates like fruc...
#1Aristotelis Kotronoulas (University of Iceland)H-Index: 1
#2Adrián López García de Lomana (University of Iceland)H-Index: 8
Last. Ottar Rolfsson (University of Iceland)H-Index: 22
view all 7 authors...
Abstract null null The use of acellular fish skin grafts (FSG) for the treatment of burn wounds is becoming more common due to its beneficial wound healing properties. In our previous study we demonstarted that FSG is a scaffold biomaterial that is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) conjugated to phosphatidylcholines. Here we investigated whether EPA and DHA derived lipid mediators are influenced during the healing of burn wounds treated with FSG. Deep partial and...
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