Current Eye Research
Papers 6,182
1 page of 619 pages (6,182 results)
#1Hao Lin (Qingdao University)H-Index: 1
#2Qian Wang (Qingdao University)H-Index: 13
Last. Guiqiu Zhao (Qingdao University)H-Index: 18
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PURPOSE This study aimed to investigate the anti-inflammatory effect and antifungal effect of punicalagin in murine fungal keratitis. METHODS We used in vitro and in vivo protocols to assess the anti-inflammatory effect and antifungal effect of punicalagin. In vitro, time kill and mycelial stain were done. In vivo, murine fungal keratitis was established and treated with PBS or PUN. clinical scores were taken on days 1, 3, and 5 post infection. The mRNA and protein levels of inflammatory factors...
#1Yi Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Yingjie Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Jibo Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 5
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Purpose null The aim of this study was to characterize the regulatory role of microRNA-29a (miR-29a) in myopia, providing support for potential biomarkers and new therapeutic targets of myopia in humans. null Methods null The miR-29a expression level was detected in the aqueous humor and peripheral blood plasma of 21 high myopic patients and eight cataract control patients using quantitative polymerase chain reaction. iTRAQ analysis of proteomes was conducted to show the regulatory effect of miR...
#1Jaya Shree (GGU: Guru Ghasidas Vishwavidyalaya)H-Index: 2
#2Amrita Singh (GGU: Guru Ghasidas Vishwavidyalaya)
Last. Surendra H. Bodakhe (GGU: Guru Ghasidas Vishwavidyalaya)H-Index: 10
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Purpose null Previously, we assessed that hypertension increases catraractogenesis. In the present study, we evaluated the effect of oral and topical administration of enalapril on two kidney one clip(2K1C) induced hypertensive cataract model by evaluating the biochemical alteration of lenticular antioxidants, ionic content, ATPase activity, protein content and careful examination of the lenticular opacity. null Materials and method null Animals were divided into normal and hypertensive animals....
#1Cui Li (Qingdao University)H-Index: 13
#2Meng-Qi Wu (Qingdao University)H-Index: 2
Last. Guiqiu Zhao (Qingdao University)H-Index: 18
view all 11 authors...
Purpose null To investigate the anti-inflammatory and anti-fungal role of α-melanocyte stimulating hormone (α-MSH) in Aspergillus Fumigatus (A. fumigatus) keratitis. null Method null Corneas of C57BL/6 mice were infected with A. Fumigatus. α-MSH (5 ul, 1x10-4mmol/ml) was given by subconjunctival injection from day 1 to day 3 post infection (p.i.). After 3 days p.i., clinical score was recored and HE staining was tested. Fungal load in mice corneas was observed by plate counting. Pro-inflammatory...
#1Man She (Fudan University)H-Index: 1
#2Bing Li (Fudan University)H-Index: 3
Last. Xiaodong Zhou (Fudan University)H-Index: 33
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Purpose null To investigate amphiregulin (AREG) expression in the sclera during the development of form-deprivation myopia (FDM) and after the recovery of FDM in guinea pigs. null Methods null Sixty-four 2-week-old guinea pigs were randomly divided into the control and FDM groups. The right eyes of animals in FDM group were covered for 2 weeks (2 W) and 4 weeks (4 W), or were covered for 4 weeks and then uncovered for the subsequent 2 weeks (6 W). The diopters and axial lengths (AL) in the right...
#1Daniela Mayr (Paracelsus Medical University)
#2Julia Preishuber-Pflügl (Paracelsus Medical University)
Last. Andrea Trost (Paracelsus Medical University)H-Index: 17
view all 9 authors...
PURPOSE/AIM OF THE STUDY Pericytes (PCs), located abluminal of endothelial cells on capillaries, are essential for vascular development and stability. They display a heterogeneous morphology depending on organ localization, differentiation state and function. Consequently, PCs show a diverse gene expression profile, impeding the usage of a unique PC marker and therefore the distinct identification of PCs. Inducible reporter mouse models represent an important tool for investigating the fate of P...
Purpose: This study aimed to evaluate a cell therapy strategy with human neural precursor cells (hNPCs) to treat diabetic retinopathy (DR) in Wistar rats induced to diabetes by injecting streptozotocin. Material and methods: Wharton's Jelly Mesenchymal stem cells (WJ-MSCs) were isolated, expanded, and seeded onto a biopolymer substrate to develop neurospheres and obtain the hNPCs. The animals were divided into three groups; non-diabetic (ND) n = four; diabetic without treatment (DM) n = nine; an...
#1Abhigna Akurathi (UI: University of Iowa)
#2Erin A. Boese (UI: University of Iowa)H-Index: 7
Last. Matthew M. Harper (VHA: Veterans Health Administration)H-Index: 18
view all 6 authors...
Purpose null The purpose of this study was to examine the expression of glial derived neurotrophic factor (GDNF), the GDNF receptors GFRα1 and GFRα2, ciliary neurotrophic factor (CNTF), and the CNTF receptor CNTFRα in normal and glaucomatous human tissue. null Methods null Human retinas were collected from 8 donors that had been clinically diagnosed and treated for glaucoma, and also from 9 healthy control donors. Immunohistochemical analysis for each trophic factor and receptor was performed. T...
#1Roberto Sanchez (CONICET: National Scientific and Technical Research Council)H-Index: 4
#2Carlos Enrique García-Guerra (UPC: Universitat Politècnica de Catalunya)H-Index: 4
Last. Jaume Pujol (UPC: Universitat Politècnica de Catalunya)H-Index: 20
view all 6 authors...
Purpose null A previous work has reported a methodology to quantify intraocular scattering using a high sensitivity double-pass instrument with a robust index, the frequency scatter index. The purpose of our study was to evaluate an adaptation of the frequency scatter index for use in clinical double-pass systems. null Methods null A prospective observational study was carried out in a group of patients with nuclear cataracts (n=52) and in a control group (n=11) using conventional double-pass sy...
#1Hehua Dai (CUMS: Capital Medical University)
#2Yang Zhang (CUMS: Capital Medical University)
Last. Genlin Li (CUMS: Capital Medical University)
view all 5 authors...
OBJECTIVE To investigate CYP4V2 gene variants and ocular clinical characteristics of Bietti corneoretinal crystalline dystrophy in China so as to provide more references for genotype and phenotype of BCD. METHODS Sixteen Chinese probands were recruited in Beijing Tongren Hospital in a retrospective study. All patients underwent CYP4V2 gene detection and ophthalmic clinical examinations. RESULTS CYP4V2 gene variants were detected in all patients. Eight variants were identified, and the most commo...
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