Current Eye Research
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#1Sergio Bonini (Università Campus Bio-Medico)H-Index: 77
#2M. Labetoulle (Université Paris-Saclay)H-Index: 4
Last. Maurizio RolandoH-Index: 34
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Background Dry eye disease (DED) is a common disorder, accounting for up to 35% of the general population. Therefore, we hypothesized that laryngopharyngeal reflux (LPR), inducing refluxate rising into airways, may involve the ocular surface and may either induce or worsen DED.Aim To investigate the prevalence and relevance of suspected LPR in DED patients and subjects with refractive problems (RP) without DED, they were defined as non-dry eye group (NEG) in clinical practice.Methods This retros...
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#2Dilara Pirhan (Kocaeli University)H-Index: 10
Last. Selenay Furat Rençber (Kocaeli University)H-Index: 4
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PURPOSE This study aimed to investigate the clinical and histopathological effects of corneal cross-linking (CXL) and matrix-regenerating agent (RGTA) treatments after corneal alkali burn. MATERIALS AND METHODS Twenty-four alkali-burned corneas from 24 rabbits were divided into three groups: control, CXL, and RGTA. All animals were investigated for epithelial healing, opacification, ulceration, and neovascularization at days 1, 7, 14, and 21 after the alkali burn. Corneas were excised and sent f...
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#1José-María Sánchez-González (University of Seville)H-Index: 6
#2David FlikierH-Index: 2
Last. Carlos Rocha-de-LossadaH-Index: 2
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PURPOSE To analyze astigmatism axis changes after tropicamide and phenylephrine combined instillation. METHOD One hundred and thirty-one eyes from sixty-six patients enrolled this cross-sectional study. An extensive ocular examination was carried out prior to tropicamide and phenylephrine instillation. Power and axis value from flat, steep, and mean keratometry were calculated using an Auto Kerato-Refractometer (AKR). Later, topography and tomography maps were evaluated with Pentacam HR® (Oculus...
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#1William H. Ridder (Marshall B. Ketchum University)H-Index: 27
#2George Comer (Marshall B. Ketchum University)H-Index: 3
Last. James Burke (AbbVie)
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PURPOSE Previous studies indicated that advanced age-related macular degeneration (AMD) affects contrast sensitivity (CS) in humans. The CS results for early/intermediate AMD patients are contradictory. The purpose of this study was to determine if CS testing discriminates early/intermediate AMD patients with normal acuity from normal patients. METHODS Forty-nine subjects (25 control and 24 early/intermediate AMD patients) were chosen for this project. The age (p = .16) and acuity (p = .34) was ...
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#1Tanja Stachon (Saarland University)H-Index: 9
#2Marwa Omar Ali (Saarland University)
Last. Nóra Szentmáry (Saarland University)H-Index: 12
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Background null Keratoconus (KC) is a corneal disorder, associated with oxidative stress, hypoxia and as several times discussed, potentially with thyroid gland dysfunction. We aimed to investigate the effect of thyroxine on transforming growth factor β1 (TGF-β1), collagen I and V (Col I and V) expression in human corneal fibroblasts (HCFs) and human keratocytes of KC corneas, in vitro. null Methods null Primary human KC-keratocytes and normal keratocytes were isolated and cultured as corneal fi...
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#1Jiajun Xie (ZJU: Zhejiang University)H-Index: 11
#2Qingyao Ning (ZJU: Zhejiang University)H-Index: 4
Last. Juan Ye (ZJU: Zhejiang University)H-Index: 11
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PURPOSE The overexpression of transforming growth factor-beta1 (TGF-β1) after surgical excision often leads to excessive fibrosis, indicating the recurrence of pterygium. The aims of the present in vitro study were to investigate the role of RhoA/ROCK signaling in regulating fibrotic effects on primary human pterygium fibroblasts (HPFs), as well as to explore the possible mechanisms of these effects. METHODS Pterygium samples were obtained from surgery, and profibrotic activation was induced by ...
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#1Timothy Hamann (UZH: University of Zurich)H-Index: 2
#2Maximilian Robert Justus Wiest (UZH: University of Zurich)H-Index: 1
Last. Sandrine A. Zweifel (UZH: University of Zurich)H-Index: 11
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PURPOSE Susac's syndrome (ScS) is a rare, potentially life-threatening auto-immune disease. Ophthalmic imaging can depict characteristic branch retinal arteriolar occlusions (BRAO) and arterial wall hyperfluorescences that form one of the three diagnostic pillars of this condition. We aim to demonstrate that ophthalmological ultrawide-field (UWF) imaging allows for a qualitative and quantitative assessment in ScS, with application in diagnostics, monitoring of treatment response, and titration o...
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#1Alev Ozcelik Kose (UHSA: University of Health Sciences Antigua)H-Index: 1
#2Serhat Imamoglu (UHSA: University of Health Sciences Antigua)H-Index: 6
Last. Nursal Melda Yenerel (UHSA: University of Health Sciences Antigua)H-Index: 3
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PURPOSE To compare peripapillary choroidal vascularity index (CVI) parameters in pseudoexfoliation glaucoma (PEG), pseudoexfoliation (PEX) syndrome, and healthy controls. METHODS A total of 240 eyes of 240 patients were included in this cross-sectional prospective study, and the three groups consisted of (i) 80 eyes of 80 patients with PEG, (ii) 80 eyes of 80 patients with PEX syndrome, and (iii) 80 healthy control eyes. Peripapillary enhanced depth imaging optical coherence tomography images we...
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#1Qin Long (Peking Union Medical College Hospital)
Last. Chen Chen (Peking Union Medical College Hospital)
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PURPOSE To investigate the effect of black carbon (BC) particles on complement activation in human corneal epithelial cells (HCECs), and determine whether this effect can be attenuated by inhibiting the NLPR3 inflammasome pathway. MATERIALS AND METHODS HCECs were treated with fresh BC (FBC) or ozone-oxidized BC (OBC) particles at a concentration of 200 μg/ml for 72hours. Complement activation was observed by detecting C5b-9 protein level in cell culture supernatant using ELISA. HCECs were transf...
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#1Weiming Liu (Soochow University (Suzhou))H-Index: 2
#2Chi Ren (PKU: Peking University)
Last. Peirong Lu (Soochow University (Suzhou))H-Index: 14
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PURPOSE To explore whether there is an association between dietary choline intake and odds of diabetic retinopathy (DR) in the US diabetic population. METHODS A cross-sectional study was conducted using the combined data of the National Health and Nutrition Examination Survey (NHANES) 2005-2008 of a complex, multistage, and probability-sampling design. Energy-adjusted choline intake was calculated separately for men and women using the residual method. Binary logistic regression adjusting for co...
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