Journal of Tissue Engineering and Regenerative Medicine
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#1João Augusto Oshiro-Junior (State University of Paraíba)H-Index: 5
#2Rafaela Moreno Barros (State University of Paraíba)
Last. Leila Aparecida Chiavacci (UNESP: Sao Paulo State University)H-Index: 19
view all 13 authors...
Guided bone regeneration (GBR) technique helps to restore bone tissue through cellular selectivity principle. Currently no osteoinductive membrane exists on the market. Osteogenic growth peptide (OGP) acts as a hematopoietic stimulator. This association could improve the quality of bone formation, benefiting more than 2.2 million patients annually. The objective of this work was to develop membranes from ureasil-polyether materials containing OGP. The membranes were characterized by differential...
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#1Yu Yang (Guangxi Medical University)
#2Xin Wang (Chinese PLA General Hospital)H-Index: 6
Last. Jinmin Zhao (Guangxi Medical University)H-Index: 28
view all 12 authors...
Xenogeneic porcine fibrin sealant (PFS), derived from porcine blood, was used as a scaffold for cartilage tissue engineering. PFS has a porous microstructure, biocompatibility and degradation, and it provides a perfect extracellular matrix environment for the adhesion and proliferation of chondrocytes. Recently, PFS in combination with autologous chondrocytes (ACs) were used to study the microstructure of PFS scaffolds and promotion effect on the proliferation and migration of ACs. In this study...
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#1Hilary E. Murray (Worcestershire Acute Hospitals NHS Trust)H-Index: 9
#2Ali Zafar (Worcestershire Acute Hospitals NHS Trust)
Last. R. Downing (Worcestershire Acute Hospitals NHS Trust)H-Index: 10
view all 8 authors...
Pancreatic islet cell transplantation has proven efficacy as a treatment for type 1 diabetes mellitus, chiefly in individuals who are refractory to conventional insulin replacement therapy. At present its clinical use is restricted, firstly by the limited access to suitable donor organs but also due to factors associated with the current clinical transplant procedure which inadvertently impair the long-term functionality of the islet graft. Of note, the physical, biochemical, inflammatory, and i...
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Insufficient vascularization during tissue repair is often associated with poor clinical outcomes. This is a concern especially when patients have critical-sized injuries, where the size of the defect restricts vascularity, or even in small defects that have to be treated under special conditions, such as after radiation therapy (relevant to tumor resection) that hinders vascularity. In fact, poor vascularization is one of the major obstacles for clinical application of tissue engineering method...
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#1Yongsheng Li (Hunan University)H-Index: 5
#2Wei Chen (Hunan University)H-Index: 1
Last. Hairong Liu (Hunan University)H-Index: 13
view all 8 authors...
Since chondrocyte hypertrophy greatly limits the efficiency of cartilage defects repairing via cartilage tissue engineering (CTE), it is critical to develop a functional CTE scaffold able to inhibit chondrocyte hypertrophy during this period of cartilage regeneration. In this study, we tested the applicability of using decellularized sturgeon cartilage ECM (dSCECM) scaffold to cease chondrocyte hypertrophy during cartilage damage repair. The dSCECM scaffolds with interconnected porous structure ...
1 CitationsSource
#1Masato Murakami (Osaka University)
#2Takami Akagi (Osaka University)H-Index: 33
Last. Mitsuru Akashi (Osaka University)H-Index: 82
view all 7 authors...
Tissue-engineered skin equivalents are reconstructed the functions of human skin and can be used as an alternative to animal experiments in basic study or as cultured skin for regenerative medicine. Recent studies confirmed that epidermal tight junctions (TJs), which are complex intercellular junctions formed in the stratum granulosum of human skin, play an important part in the formation of the skin barrier function. In well-formed reconstructed human skin models, there are several reports on t...
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#1Hideyoshi Sawada (Nagoya University)H-Index: 1
#2Shigeru Kurimoto (Nagoya University)H-Index: 11
Last. Hitoshi Hirata (Nagoya University)H-Index: 26
view all 5 authors...
Motoneuron transplantation into peripheral nerves undergoing Wallerian degeneration may have applications in treating diseases causing muscle paralysis. We investigated whether functional reinnervation of denervated muscle could be achieved by early or delayed transplantation after denervation. Adult rats were assigned to six groups with increasing denervation periods (0, 1, 4, 8, 12, and 24 weeks) before inoculation with culture medium containing (transplantation group) or lacking (surgical con...
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#1Christine Schmitt (MLU: Martin Luther University of Halle-Wittenberg)
#2Florian Radetzki (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 13
Last. Stefan Schwan (Fraunhofer Society)H-Index: 7
view all 17 authors...
The potential therapeutic benefit of adipose-derived stem cells (ASCs) encapsulated in an injectable hydrogel for stimulating intervertebral disc (IVD) regeneration has been assessed by a number of translational and preclinical studies. However, previous work has been primarily limited to small animal models and short-term outcomes of only a few weeks. Long-term studies in representative large animal models are crucial for translation into clinical success, especially for permanent stabilization...
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#1Michella H. Hagmeijer (UU: Utrecht University)H-Index: 3
#2Jasmijn V. Korpershoek (UU: Utrecht University)H-Index: 3
Last. Lucienne A. Vonk (UU: Utrecht University)H-Index: 17
view all 11 authors...
Meniscus regeneration could be enhanced by targeting meniscus cells and mesenchymal stromal cells (MSCs) with the right growth factors. Combining these growth factors with the Collagen Meniscus Implant (CMI®) could accelerate cell ingrowth and tissue formation in the implant and thereby improve clinical outcomes. Using a transwell migration assay and a micro-wound assay, the effect of insulin-like growth factor-1, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), ...
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#1Arvind Manikantan Padma (University of Gothenburg)H-Index: 8
#2Ahmed Baker Alshaikh (University of Gothenburg)H-Index: 2
Last. Mats Hellström (University of Gothenburg)H-Index: 31
view all 8 authors...
Scaffolds derived from decellularized tissue possess many advantages for bioengineering applications, including for novel infertility treatments. However, the decellularization process results in allogenic-independent damage-associated molecular patterns (DAMPs). This field is poorly studied, in particular for uterus bioengineering applications. An increased knowledge concerning the immune system activation after transplantation of decellularized tissue will enable safer construct development an...
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Top fields of study
Anatomy
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Mesenchymal stem cell
Tissue engineering
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