Hypertension Research
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#1Zhang Cui (CSU: Central South University)
#2Yao Jiamei (CSU: Central South University)
Last. Zhong Guangwei (CSU: Central South University)
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Age-related functional decline is a physiological phenomenon that occurs in all organ systems. However, the acceleration and early occurrence of this process are observed in cardiovascular pathologies, including hypertension. This study aimed to investigate SIRT1-PTEN signaling in aortic tissue from spontaneously hypertensive rats (SHRs) and changes in SIRT1 and PTEN expression following treatment with Pinggan-Qianyang decoction (PGQYD) and explore the mechanism involved in the treatment of hype...
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#1Shin Kawasoe (Kadai: Kagoshima University)H-Index: 4
#2Takuro Kubozono (Kadai: Kagoshima University)H-Index: 19
Last. Mitsuru Ohishi (Kadai: Kagoshima University)H-Index: 52
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Low and high serum uric acid levels are associated with an increased risk of cardiovascular diseases. However, whether there is a similar association between serum uric acid levels and blood pressure abnormalities has not yet been elucidated. Data from 236,221 individuals (age, 56.0 ± 15.0 years; 107,146 men) who underwent routine health checkups were analyzed. Participants with a serum uric acid level ≤2.0 mg/dL were separated, and the remaining participants were divided into quartiles accordin...
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#1Yoichi Nozato (Osaka University)H-Index: 5
#2Koichi Yamamoto (Osaka University)H-Index: 26
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#1Qifeng Yang (Guangzhou Medical University)
#2Zizhou Zhang (Guangzhou Medical University)H-Index: 1
Last. Xinyi Liu (Guangzhou Medical University)
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#1Byeong Keuk Kim (Yonsei University)H-Index: 26
#2Hyo-Soo Kim (New Generation University College)H-Index: 16
Last. Hyuck Moon Kwon (Yonsei University)H-Index: 28
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The objective of this work was to investigate the long-term safety and efficacy of renal denervation in Korean patients from the Global SYMPLICITY Registry (GSR). GSR Korea is a substudy of GSR with additional inclusion and exclusion criteria compared to GSR, including inclusion criteria of office systolic blood pressure ≥160 mmHg, or ≥150 mmHg for type 2 diabetes patients, while receiving 3 or more antihypertensive medications without changes for 2 weeks prior to enrollment. Renal denervation w...
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To evaluate the effects of isometric handgrip exercise training (IHET) on blood pressure and heart rate variability in hypertensive subjects. Five databases were searched for randomized clinical trials in English, Spanish, or Portuguese evaluating the effect of IHET vs. no exercise on blood pressure (systolic and/or diastolic) and/or heart rate variability (low frequency [LF], high frequency [HF], and/or LF/HF ratio) through December 2020. Random-effects meta-analyses of mean differences (MDs) a...
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#1Tiantian Sang (Peking Union Medical College)H-Index: 1
#2Naqiang Lv (Peking Union Medical College)H-Index: 9
Last. Wei Zhang (Peking Union Medical College)H-Index: 1
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Arterial stiffness has been suggested as an independent cardiovascular risk factor. This systematic review and meta-analysis aimed to quantify the association between brachial-ankle pulse wave velocity (baPWV) and prognosis in atherosclerotic cardiovascular disease (ASCVD) patients. The PubMed, EMBASE, and Cochrane Library databases were searched for cohort studies examining the association of high baPWV with prognosis in ASCVD patients. High baPWV was defined by the cutoffs provided by each stu...
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#1Masato Furuhashi (Sapporo Medical University)H-Index: 31
#2Yukimura Higashiura (Sapporo Medical University)H-Index: 7
Last. Hirofumi Ohnishi (Sapporo Medical University)H-Index: 23
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Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation in purine metabolism, is involved in reactive oxygen species generation. Plasma XOR activity has been shown to be a novel metabolic biomarker related to obesity, liver dysfunction, hyperuricemia, dyslipidemia, and insulin resistance. However, the association between plasma XOR activity and hypertension has not been fully elucidated. We investigated the association of hypertension with plasma XOR activity ...
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Decreased secretion of melatonin was reported to be associated with an enhanced risk of hypertension and diabetes. However, the effect of melatonin on gestational hypertension (GH) and the underlying mechanism remain unclear. A GH mouse model was established via electrical stimulation. The hypertensive phenotypes were indicated by systolic blood pressure (SBP) and urinary protein levels. Uterine artery (UtA) endothelial function was detected by relaxation, peak systolic velocity (PSV), end-diast...
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#1Hironori Nakagami (Osaka University)H-Index: 52
#2Hiroki Hayashi (Osaka University)H-Index: 13
Last. Ryuichi Morishita (Osaka University)H-Index: 103
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There is currently a respiratory disease outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After rapid development, RNA vaccines and adenoviral vector vaccines were approved within a year, which has demonstrated the strong impact of preventing infectious diseases using gene therapy technology. Furthermore, intensive immunological analysis has been performed to evaluate the efficiency and safety of these vaccines, potentially allowing for rapid progress in vaccine t...
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Top fields of study
Endocrinology
Cardiology
Angiotensin II
Diabetes mellitus
Medicine
Blood pressure