Seminars in Diagnostic Pathology
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#1Cesar A. Moran (University of Texas MD Anderson Cancer Center)H-Index: 76
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#1Julia Prays (Karolinska University Hospital)
#2Cristian Ortiz-Villalón (Karolinska University Hospital)H-Index: 4
Thymic epithelial tumors (TETs) are extremely rare and represent the most frequent tumors of the anterior mediastinum originating from epithelial cells in the thymus. Thymic epithelial tumors include thymomas (TM), thymic carcinomas (TC) and thymic neuroendocrine neoplasms (TNEN). Thymomas are the most predominant and are associated with autoimmune diseases. The available data suggests that the different histological subtypes have specific molecular alterations. Thymic carcinoma shows recurrent ...
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#1Xiaoqiong Wang (University of Texas MD Anderson Cancer Center)
#2Wei Wang (University of Texas MD Anderson Cancer Center)H-Index: 17
Last. Andrés E. Quesada (University of Texas MD Anderson Cancer Center)H-Index: 10
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The mediastinum contains essentially all major intrathoracic organs except for the lungs. A variety of both benign and malignant tumors can involve the mediastinum, of which lymphoma is the most common malignancy. Compared to secondary mediastinal involvement by systemic lymphomas, primary mediastinal lymphomas are less common with several specific entities that are mainly confined to mediastinal lymph nodes, and/or thymus. This review will summarize the clinical, histologic, immunophenotypic an...
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#1Sylvie Lantuejoul (UGA: University of Grenoble)H-Index: 65
#2Daniel Pissaloux (UCBL: Claude Bernard University Lyon 1)H-Index: 10
Last. Anne McLeer (UGA: University of Grenoble)H-Index: 2
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NUT carcinoma of the thorax is a rare and very aggressive tumor, whose definition is based on the demonstration of a nuclear protein in testis (NUTM1; also known as NUT) gene fusion on 15q14 with different partners from the bromodomain-containing proteins gene family. This fusion results in an activation of MYC oncoprotein responsible for the tumor's aggressivity. NUT carcinoma arises preferentially in young adults, presenting a large thoracic mass frequently associated with lymph nodes, bone or...
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#1Nahyun Jo (University of Texas MD Anderson Cancer Center)
#2Girish S. Shroff (University of Texas MD Anderson Cancer Center)H-Index: 9
Last. Mylene T. Truong (University of Texas MD Anderson Cancer Center)H-Index: 42
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Abstract null null In the imaging of the mediastinum, benign lesions mimicking malignancy constitute potential pitfalls in interpretation. Localization and characteristic imaging features are key to narrow the differential diagnosis and avoid potential pitfalls in interpretation. Based on certain anatomic landmarks, the mediastinal compartment model enables accurate localization. Depending on the anatomic origin, mediastinal lesions can have various etiologies. The anatomic location and structur...
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#1Julie Lin (University of Texas MD Anderson Cancer Center)
#2Carlos A. Jimenez (University of Texas MD Anderson Cancer Center)H-Index: 28
Acute mediastinitis is a rare infection that carries high morbidity and mortality. They are complications seen most often with deep sternal wound infections from surgeries with median sternotomies, oropharyngeal and odontogenic infections and esophageal perforations. These conditions should be promptly recognized and treated. Mediastinal granulomas are focal, mass-like lesions commonly resulting from prior granulomatous infections. They are regarded as benign, self-resolving lesions however can ...
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#1Joon Hyuk Choi (Yeungnam University)H-Index: 21
#2Jae Y. Ro (Cornell University)H-Index: 112
Neuroblastic tumors are a group of tumors of the sympathetic ganglia and adrenal medulla that derive from primordial neural crest cells. These tumors include neuroblastoma, intermixed ganglioneuroblastoma, nodular ganglioneuroblastoma, and ganglioneuroma. Neuroblastomas are the most common extracranial solid tumor arising in childhood and may occur in different anatomic sites. Neuroblastic tumors are common mesenchymal tumors of the mediastinum. Herein, we describe advances in our understanding ...
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#1Diana M. Oramas (University of Texas MD Anderson Cancer Center)H-Index: 1
#2Cesar A. Moran (University of Texas MD Anderson Cancer Center)H-Index: 76
ABSTRACT null null Over the years the nomenclature of thymomas has been debated regarding the best manner in which these tumors should be grouped. In every schema presented thus far, the main issue has been the presence or lack of lymphocytes and accordingly, the tumors have been place into a specific category. However, even though this concepts applies for most of the cases, there are numerous tumors that do not necessarily fit into those categories as either the thymomas show another cellular ...
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#1Deepali Jain (AIIMS: All India Institute of Medical Sciences)H-Index: 25
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#1Diana M. Oramas (University of Texas MD Anderson Cancer Center)H-Index: 1
#2Cesar A. Moran (University of Texas MD Anderson Cancer Center)H-Index: 76
ABSTRACT null null Cystic lesions of the anterior mediastinum represent a well-known group of benign lesions that are relatively common in the general practice, namely in the pediatric age group. In the adult population, multilocular thymic cyst (MTC) plays an important role in occurrence as it presents as a cystic anterior mediastinal mass that clinically may mimic another anterior mediastinal tumor. In general, MTC is of rather unusual occurrence and its histopathological features have been we...
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