Journal of Investigational Allergology and Clinical Immunology
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Objectives null Deficiency of adenosine deaminase 2 (DADA2) is a rare disease with varying phenotypes and disease outcomes. We aimed to summarize the treatments of DADA2 and to explore the factors associated with disease outcome. null Material and methods null A systemic literature review of DADA2 was conducted. Cases were included if they had documented detailed genotypes, phenotypes, treatment protocols and outcomes. Patients were categorized into uncontrolled and controlled groups. Factors as...
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Last. Joaquín Sastre (ISCIII: Carlos III Health Institute)H-Index: 65
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BACKGROUND AND OBJECTIVE Asthma is a chronic inflammatory condition of the airways with a complex pathophysiology. Stratification of asthma subtypes into phenotypes and endotypes should move the field forward, making treatment more effective and personalized. Eosinophils are the key inflammatory cells involved in severe eosinophilic asthma. Due to the health threat posed by eosinophilic asthma, there is a need for reliable biomarkers to identify patients and treat them properly with novel biolog...
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#1S Gelis (University of Barcelona)
#2M RuedaH-Index: 1
Last. A Valero (University of Barcelona)H-Index: 20
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BACKGROUND AND OBJECTIVE Shellfish allergy is an important cause of food allergy and anaphylaxis worldwide. Several allergenic proteins have been described in the last few years, but the only diagnostic tool that allows discrimination between allergic and non-allergic sensitized subjects is still the oral food challenge (OFC). Objective: The aim of this study was to evaluate the usefulness of nasal allergen provocation test (NAPT) as a diagnostic tool in the diagnosis of shellfish allergy. MATER...
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#1Lennart M. Roesner (MHH: Hannover Medical School)H-Index: 11
Last. Christiane HilgerH-Index: 28
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Background null Immediate as well as delayed-type hypersensitivity immune reactions to pet-borne allergens are commonly observed in atopic diseases. Further on in atopic dermatitis (AD), cross-reactivity to self-proteins is discussed to contribute to the disease. Human cystatin A and the cat allergen Fel d 3 belong to the cystatin family, an evolutionary conserved protein family. The objective of the present study was to assess cross-reactivity between mammalian cystatins and to analyze T cell r...
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Top fields of study
Immunoglobulin E
Immunology
Allergy
Asthma
Anesthesia
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