Endocrine Pathology
Papers 1,341
1 page of 135 pages (1,341 results)
#1Noriko KimuraH-Index: 24
#2Kiyoto Shiga (Iwate Medical University)H-Index: 17
Last. Takayuki Katabami (St. Marianna University School of Medicine)H-Index: 2
view all 13 authors...
Paragangliomas (PGLs) are neural-crest-derived, non-epithelial neuroendocrine tumors distributed along the parasympathetic and sympathetic nerves. Head-and-neck PGLs (HNPGLs) have been recognized as nonchromaffin, nonfunctional, parasympathetic tumors. By contrast, thoracoabdominal paragangliomas and pheochromocytomas (PPGLs) are chromaffin, functional, sympathetic tumors. Although HNPGLs and PPGLs have the same histological structure, the zellballen pattern, composed of chief and sustentacular ...
#1Arthur S. Tischler (Tufts University)H-Index: 60
#2Sylvia LAsa (University Hospitals of Cleveland)
Last. Ozgur Mete (UHN: University Health Network)H-Index: 37
view all 5 authors...
#1Johan O. Paulsson (KI: Karolinska Institute)H-Index: 9
#2Jan Zedenius (KI: Karolinska Institute)H-Index: 43
Last. C. Christofer Juhlin (Karolinska University Hospital)H-Index: 26
view all 3 authors...
#1Wolfgang Saeger (UHH: Universität Hamburg)H-Index: 25
#2Christian Mawrin (OvGU: Otto-von-Guericke University Magdeburg)H-Index: 62
Last. Frank Jacobsen (UHH: Universität Hamburg)H-Index: 14
view all 5 authors...
We report two pituitary neuroendocrine tumors (PitNETs) with very high Ki67 labeling indices, many mitoses and TP53 mutation (nearly all tumor cell nuclei were positive for p53). One of the tumors had bone and liver metastases. One was a corticotroph cell tumor; the other was a lactotroph tumor. The classification of these tumors is the subject of this discussion. Traditionally, pituitary carcinomas are only diagnosed by demonstration of metastases according to the 2017 WHO classification. In co...
#1Tam N.M. Ngo (Pham Ngoc Thach University of Medicine)H-Index: 4
#2Trang T B Le (Ho Chi Minh City Medicine and Pharmacy University)
Last. Huy Gia Vuong (UO: University of Oklahoma)H-Index: 16
view all 9 authors...
Primary (or de novo) anaplastic thyroid carcinoma (ATC) is ATC without pre-existing history of differentiated thyroid carcinoma (DTC) and no co-existing DTC foci at the time of diagnosis. Secondary ATC is diagnosed if the patient had a history of DTC or co-existing DTC components at time of diagnosis. This study aimed to investigate the incidence, clinical presentations, outcomes, and genetic backgrounds of primary versus secondary ATCs. We searched for ATCs in our institutional databases and th...
#1Sounak Gupta (Mayo Clinic)H-Index: 18
#2Helen Won (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 34
Last. Nitya Raj (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 10
view all 18 authors...
Molecular characterization of adrenocortical carcinomas (ACC) by The Cancer Genome Atlas (TCGA) has highlighted a high prevalence of TERT alterations, which are associated with disease progression. Herein, 78 ACC were profiled using a combination of next generation sequencing (n = 76) and FISH (n = 9) to assess for TERT alterations. This data was combined with TCGA dataset (n = 91). A subset of borderline adrenocortical tumors (n = 5) and adrenocortical adenomas (n = 7) were also evaluated. The ...
#1Tae Nakano-Tateno (University of Alberta)H-Index: 4
#2Motoyasu Satou (University of Alberta)H-Index: 2
Last. Constance L. Chik (University of Alberta)H-Index: 28
view all 8 authors...
Corticotroph carcinomas and aggressive corticotroph tumors can be resistant to conventional therapy, including surgery, radiotherapy, and medical treatment. Recent evidence suggests that temozolomide (an oral alkylating agent) administered with capecitabine (pro-drug of 5-fluorouracil) may improve progression-free survival in patients with high-risk corticotroph tumors and carcinomas. This led to the use of capecitabine and temozolomide (CAPTEM) in two patients, one with a corticotroph carcinoma...
#1Roberta Maragliano (University of Insubria)H-Index: 9
#2Laura Libera (University of Insubria)H-Index: 5
Last. Fausto Sessa (University of Insubria)H-Index: 40
view all 12 authors...
Primary ovarian neuroendocrine neoplasms (Ov-NENs) are infrequent and mainly represented by well-differentiated forms (neuroendocrine tumors - NETs - or carcinoids). Poorly differentiated neuroendocrine carcinomas (Ov-NECs) are exceedingly rare and only few cases have been reported in the literature. A subset of Ov-NECs are admixed with non-neuroendocrine carcinomas, as it occurs in other female genital organs, as well (mostly endometrium and uterine cervix), and may be assimilated to mixed neur...
#1Ja-Seong Bae (Catholic University of Korea)H-Index: 11
#2Seung-Hyun Jung (Catholic University of Korea)H-Index: 21
Last. Chan Kwon Jung (Catholic University of Korea)H-Index: 44
view all 8 authors...
Follicular-patterned tumors of the thyroid in the adult population frequently harbor RAS mutations or PAX8-PPARG rearrangement, but little is known about molecular profiles in the pediatric patients with thyroid tumors, which is rare. To identify the molecular profile of pediatric follicular-patterned tumors, we enrolled 41 pediatric patients with follicular-patterned tumors from two institutions. We did next-generation sequencing using a mutation panel targeting 49 thyroid-tumor-related genes a...
#1Emily Bulson (University Hospitals of Cleveland)
#2Sarah Chaaban (University Hospitals of Cleveland)
Last. Sylvia L. Asa (University Hospitals of Cleveland)H-Index: 114
view all 3 authors...
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