Expert Opinion on Drug Delivery
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#1Ana Cláudia Paiva-Santos (UC: University of Coimbra)H-Index: 1
#2Filipa Mascarenhas-Melo (UC: University of Coimbra)H-Index: 8
Last. Francisco Veiga (UC: University of Coimbra)H-Index: 70
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Introduction: Acne vulgaris is a chronic inflammatory skin disorder that affects an extremely concerning percentage of teenagers (ca. 85%), gathering serious negative impacts on the social life and psychological well-being of individuals. Conventional topical formulations for acne show low tolerability and side effects, such as skin irritation, leading to a decrease in the user's adherence to therapy. Nanotechnology-based formulations were developed as new strategies for topical acne management,...
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#1Srividya Gorantla (BITS: Birla Institute of Technology and Science)H-Index: 7
Last. Gautam Singhvi (BITS: Birla Institute of Technology and Science)H-Index: 17
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#1Garima Sharma (Panjab University, Chandigarh)H-Index: 1
#2Manuhaar Sharma (Panjab University, Chandigarh)
Last. Indu Pal Kaur (Panjab University, Chandigarh)H-Index: 40
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BACKGROUND Dermal disorders, owing to disruption of skin-microflora balance can be served by direct application of probiotics. However, there are few topical whole probiotic products in market because of (i) loss of viability during manufacturing and storage, and (ii) inadequate germination and retention on skin. Presently we report a novel (IPA 201811010395) emulgel incorporating Bacillus coagulans (Unique IS-2) for possible topical use. METHODS Developed emulgel was characterized for particle ...
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#1Ripandeep Kaur (Panjab University, Chandigarh)H-Index: 2
#2Varun Gorki (Panjab University, Chandigarh)H-Index: 2
Last. Bhupinder Singh (Panjab University, Chandigarh)H-Index: 63
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Background null Lumefantrine (LMF) is first-line antimalarial drug, possesses activity against almost all human malarial parasites, but the in vivo activity of this molecule gets thwarted due to its low and inconsistent oral bioavailability (i.e., 4-12 %) owing to poor biopharmaceutical attributes. null Methods null Lumefantrine phospholipid complex (LMF-PC) was prepared by rota-evaporation method following Job's plot technique for the selection of apt stoichiometric ratios. Docking studies were...
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#1David J. Brayden (UCD: University College Dublin)H-Index: 44
#2Sam Maher (RCSI: Royal College of Surgeons in Ireland)H-Index: 22
Introduction null : The FDA approval of oral semaglutide for type 2 diabetes (2019) and oral octreotide for acromegaly (2020) is evidence that selected niche peptides can be administered orally if formulated with selected intestinal permeation enhancers. null Areas covered null We evaluated the oral octreotide formulation, MYCAPSSA® (Chiasma Pharmaceuticals, Needham, MA, USA). An outline of the current standard of care in acromegaly and the benefits of oral octreotide versus depot injections is ...
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#1Pedro Gonzalez-Cruz (TTU: Texas Tech University)H-Index: 2
#2Harvinder S. Gill (TTU: Texas Tech University)H-Index: 28
Introduction: The oral route of vaccination is pain- and needle-free and can induce systemic and mucosal immunity. However, gastrointestinal barriers and antigen degradation impose significant hurdles in the development of oral vaccines. Live attenuated viruses and bacteria can overcome these barriers but at the risk of introducing safety concerns. As an alternative, particles have been investigated for antigen protection and delivery, yet there are no FDA-approved oral vaccines based on particl...
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Background: Self-injection, particularly of biologics, has become a mainstay of chronic disease management. Despite labeling requirement for healthcare provider (HCP) training, current injection initiation experiences have been shown to be suboptimal. This study characterizes gaps in training and support during initiation and identifies rationales to inform solutions.Methods: We enrolled HCPs (n=18) performing routine biologic initiation and patients (n=24) currently self-injecting biologics. Pa...
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#1Ghada M. El-Zaafarany (Ain Shams University)H-Index: 3
#2Rasha T A Abdel-Aziz (Minia University)H-Index: 7
Last. Maha Nasr (Ain Shams University)H-Index: 23
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INTRODUCTION : Coenzyme Q10 (CoQ10) is an antioxidant molecule with anti-aging activity on human hair, and because of its pharmaceutical limitations such as large molecular weight, high lipophilicity and poor water solubility, its therapeutic effectiveness has been hampered. Therefore, different vesicular nanocarriers were developed in the current work, for enhancement of the skin penetration of CoQ10 for treatment of androgenic alopecia. AREAS COVERED In order to overcome the poor skin penetrat...
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#1Miguel Pereira-Silva (UC: University of Coimbra)H-Index: 8
#2Gaurav Chauhan (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 11
Last. Ana Cláudia Santos (UC: University of Coimbra)H-Index: 14
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Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a particular coronavirus strain responsible for the coronavirus disease 2019 (COVID-19), accounting for more than 2.8 million deaths worldwide. Several health-related strategies have been successfully developed to contain the rapidly-spreading virus across the globe, towards reduction of both disease burden and infection rates. Particularly, attention has been focused on either the development of novel drugs and vaccin...
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INTRODUCTION Autophagy is a critical housekeeping pathway to remove toxic protein aggregates, damaged organelles, providing cells with bioenergetic substrates needed to survive under adverse conditions. Since altered autophagy is associated with diverse diseases, its pharmacological modulation is considered of therapeutic interest. Nanomedicines may reduce the toxicity and improve the activity of toxic autophagy modulatory drugs (amd). AREAS COVERED The status of the most relevant anti-tumor, an...
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