#1Gohar Tsakanova(Armenian National Academy of Sciences)H-Index: 4
#2Elina Arakelova(Armenian National Academy of Sciences)H-Index: 4
Last. Nelly Babayan(Armenian National Academy of Sciences)H-Index: 5
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Purpose null To describe the contribution of women scientists in the development of biomedical studies conducted on research facilities based on the ultrashort pulsed laser technologies in Armenia. null Conclusion null Given the opportunities provided by the ultrashort pulsed laser driven two-photon microscopy and electron beam linac facilities at CANDLE Synchrotron Research Institute, the Armenian women scientists initiated and conducted interdisciplinary research to understand of the biomedica...
Purpose null Emerging evidence has shown that radiotherapy is an effective treatment for hepatocellular carcinoma (HCC), Micro(mi)RNAs are involved in regulating radiosensitivity in many cancers. MiR-122 accounts for approximately 70% of all cloned miRNAs in the liver, but there are few reports about whether it is involved in regulating of radiosensitivity in HCC cells. null Materials and methods null HCC cells (HepG2 and Huh7) overexpressing miR-122 were constructed by transfecting them with le...
PURPOSE To measure medium borne bystander effects, to study the influence of radioadaptive response (RAR) on bystander response, and to discover reliable radioresponsive biomarkers in radio-adapting frogs from Duke Swamp contaminated with an above-background radiation level and in naive frogs from Twin Lake as the background control site. MATERIALS AND METHODS Frogs were captured at Duke Swamp and Twin Lake and brought to the lab at the Canadian Nuclear Laboratories facility. Half of the frogs f...
Last. Bleddyn Jones(Green Templeton College)H-Index: 7
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Purpose null A graphical user interface (GUI) was developed to aid in the assessment of changes in the radiation tolerance of spinal cord/similar central nervous system tissues with time between two individual treatment courses. null Methods null The GUI allows any combination of photons, protons (or ions) to be used as the initial, or retreatment, radiotherapy courses. Allowances for clinical circumstances, of reduced tolerance, can also be made. The radiobiological model was published previous...
Purpose: The interest in exploiting Auger emitters in cancer therapy stems from their high linear energy transfer (LET)-type radiation damage to DNA. However, the design of Auger-emitter labeled vehicles that target the Auger cascade specifically to the DNA of tumour cells is challenging. Here we suggest a possible approach to evaluate tumour-targeting Auger-labeled conjugates by assessing the impact of a radioprotector known to be effective in protecting from low LET radiation, but not high LET...
PURPOSE In a nuclear or radiological event, an early diagnostic or prognostic tool is needed to distinguish unexposed from low- and highly exposed individuals with the latter requiring early and intensive medical care. Radiation-induced gene expression (GE) changes observed within hours and days after irradiation have shown potential to serve as biomarkers for either dose reconstruction (retrospective dosimetry) or the prediction of consecutively occurring acute or chronic health effects. The ad...
PURPOSE The threat of serious radiation exposures to members of the public from radiological incidents and nuclear events has led to intensive study of a number of emergency dosimetry techniques for purposes of triage. As such, a national laboratory of retrospective dosimetry was established in our institute. The purpose of this work is to provide a summary of the well-established and already implemented retrospective physical dosimetry techniques based on thermoluminescence (TL), optically stim...
Last. Zhiyong Xu(SJTU: Shanghai Jiao Tong University)H-Index: 3
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This research compared differences of dosimetric and biological parameters between PET/CT-guided isotoxic SIB-IMRT plans and conventional radiotherapy plans for patients with LA-NSCLC, and it also ...
#1Xin Li(HAUST: Henan University of Science and Technology)
#2Lei Chen(HAUST: Henan University of Science and Technology)
Last. Xinyue Pang(HAUST: Henan University of Science and Technology)
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BACKGROUND Ionizing radiation, especially heavy ion (HI) beams, has been widely used in biology and medicine. However, the mechanism of membrane damage by such radiation remains primarily uncharacterized. PURPOSE Transcriptomic profiles of Escherichia coli (E. coli) treated with HI illustrated the response mechanisms of the membrane, mainly ABC transporters, related genes regulated by antibiotics treatment through enrichment analyses of GO and KEGG. The networks of protein-protein interactions i...