Advances in Experimental Medicine and Biology
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#1Rick H. Cote (UNH: University of New Hampshire)H-Index: 23
#2Richa Gupta (UNH: University of New Hampshire)H-Index: 3
Last. Xin Wang (UNH: University of New Hampshire)H-Index: 1
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The photoreceptor phosphodiesterase (PDE6) is a member of large family of Class I phosphodiesterases responsible for hydrolyzing the second messengers cAMP and cGMP. PDE6 consists of two catalytic subunits and two inhibitory subunits that form a tetrameric protein. PDE6 is a peripheral membrane protein that is localized to the signal-transducing compartment of rod and cone photoreceptors. As the central effector enzyme of the G-protein coupled visual transduction pathway, activation of PDE6 cata...
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#1Shemse Sebre (College of Health Sciences, Bahrain)H-Index: 1
#2Woldaregay Erku Abegaz (College of Health Sciences, Bahrain)H-Index: 9
Last. Adane Mihret (College of Health Sciences, Bahrain)H-Index: 19
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INTRODUCTION The hospital environment contributes to the spread of Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE), which are contributing to increased morbidity and mortality rates. The present study was carried out to detect environmental contamination, antimicrobial susceptibility testing of ESBL-PE, and to explore molecular characterization of ESBL encoding genes. METHODS A cross-sectional study was conducted within the intensive care units (ICUs) of Tikur Anbessa Specia...
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Infection and the formation of biofilms have been shown to have a significant role in increased inflammation and delayed wound healing. Wound irrigation solutions are used to debride wounds, removing cell debris and infecting microorganisms, therefore preventing infection. The aim of this study was to evaluate a Polihexanide (PHMB) based wound irrigation solution, Octenidine HCl based wound irrigation solution and electrolysed water based wound care solution for antibiofilm efficacy against Stap...
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#1Mariola Seń (Wrocław Medical University)H-Index: 3
#2Luba Jakubowska (Wrocław Medical University)H-Index: 1
Last. Beata Jankowska-Polańska (Wrocław Medical University)H-Index: 16
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This study assessed the risk of falls, the incidence of frailty, cognition, and nutritional status in people aged over 65 in the context of the treatment facility. To this end, we compared a group of 99 non-hospitalized patients treated in primary healthcare facilities with a group of 100 patients hospitalized in a geriatric ward. It was a survey-type study based on the following questionnaires: Mini-Mental State Examination, Tilburg Frailty Indicator, Mini Nutritional Assessment, and the Tinett...
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#1Derya Sağraç (Yeditepe University)H-Index: 1
#2Hatice Burcu Şişli (Yeditepe University)H-Index: 3
Last. Ayşegül Doğan (Yeditepe University)H-Index: 16
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Improvements in stem cell-based research and genetic modification tools enable stem cell-based tissue regeneration applications in clinical therapies. Although inadequate cell numbers in culture, invasive isolation procedures, and poor survival rates after transplantation remain as major challenges, cell-based therapies are useful tools for tissue regeneration.Organoids hold a great promise for tissue regeneration, organ and disease modeling, drug testing, development, and genetic profiling stud...
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This article aims to present how the advanced solutions of artificial intelligence and precision medicine work together to refine medical management. Multi-omics seems the most suitable approach for biological analysis of data on precision medicine and artificial intelligence. We searched PubMed and Google Scholar databases to collect pertinent articles appearing up to 5 March 2021. Genetics, oncology, radiology, and the recent coronavirus disease (COVID-19) pandemic were chosen as representativ...
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#1Sophia FernandesH-Index: 3
#2Lalita LimayeH-Index: 16
Last. Vaijayanti Kale (Symbiosis International University)H-Index: 5
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Hematopoietic stem cells (HSCs) and their development are one of the most widely studied model systems in mammals. In adults, HSCs are predominantly found in the bone marrow, from where they maintain homeostasis. Besides bone marrow and mobilized peripheral blood, cord blood is also being used as an alternate allogenic source of transplantable HSCs. HSCs from both autologous and allogenic sources are being applied for the treatment of various conditions like blood cancers, anemia, etc. HSCs can ...
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Advances in medicine comprising diverse diagnostic and management modalities call for a bundle approach to improve patient care. This study aimed to present diagnostic patterns in patients with multiple intracranial lesions together with connoted survival implications. We retrospectively reviewed medical files of 85 patients with tumor and non-tumor intracranial lesions. Metastatic brain lesions were identified in 23.5% of patients. Neurological pathogenesis underlay 29.4%, infectious 21.2%, and...
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#1Marco Folci (Humanitas University)H-Index: 5
#1Marco FolciH-Index: 6
Last. Enrico Brunetta (Humanitas University)H-Index: 18
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Eosinophils are a subset of differentiated granulocytes which circulate in peripheral blood and home in several body tissues. Along with their traditional relevance in helminth immunity and allergy, eosinophils have been progressively attributed important roles in a number of homeostatic and pathologic situations. This review aims at summarizing available evidence about eosinophils functions in homeostasis, infections, allergic and autoimmune disorders, and solid and hematological cancers.Their ...
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