Modern Pathology
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#1Natalia Buza (Yale University)H-Index: 24
#2Pei Hui (Yale University)H-Index: 36
Investigations in recent decades have exploited tissue DNA genotyping as a powerful ancillary tool for the precision diagnosis and subclassification of gestational trophoblastic disease. As lesions of gestational origin, the inherited paternal genome, with or without copy number alterations, is the fundamental molecular basis for the diagnostic applications of DNA genotyping. Genotyping is now considered the gold standard in the confirmation and subtyping of sporadic hydatidiform moles. Although...
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#1Jože Pižem (University of Ljubljana)H-Index: 10
#2Alenka Matjašič (University of Ljubljana)H-Index: 4
Last. Katarina Dimnik (University of Ljubljana)
view all 6 authors...
Fibroma of tendon sheath (FTS) is an uncommon benign myofibroblastic neoplasm that arises in association with tenosynovial tissue. Fusions of the USP6 gene have been recently documented in a proportion of so-called "cellular FTS" but not in "classic FTS". It remains unknown whether FTS can be defined by a USP6 fusion, regardless of cellularity, and what are USP6 fusion-negative "cellular FTS". Furthermore, FTS with low cellularity seems to be frequently confused with desmoplastic fibroblastoma. ...
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#1Josephine K. Dermawan (Cleveland Clinic)H-Index: 9
#2Elizabeth M. Azzato (Cleveland Clinic)H-Index: 6
Last. Jennifer S. Ko (Cleveland Clinic)H-Index: 21
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Gene rearrangements involving the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase gene have been identified in various neoplasms, including inflammatory myofibroblastic tumor and epithelioid fibrous histiocytoma. We present an ALK-rearranged cutaneous soft tissue tumor with unique morphologic and immunophenotypic features that are not shared by other entities with ALK rearrangements. The six cases involved two females and four males, aged 18-84 (mean 51) years old. Three tumors were on...
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#1Farhan Khan (WashU: Washington University in St. Louis)
#2John S.A. Chrisinger (WashU: Washington University in St. Louis)H-Index: 6
Last. Horacio M. Maluf (WashU: Washington University in St. Louis)H-Index: 18
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Myofibroblastic stromal hyperplasia (MSH) is the proposed name for a benign spindle cell proliferation of the mammary stroma, which often raises clinical and radiographic concern for a mass or a malignant process. Ten cases were retrieved from the files of our institution. All presented as a mammographic abnormality. Patients ranged in age from 24 to 67 years. Seven were <50 years old. The salient histopathologic aspect was the proliferation of benign appearing spindle cell within the intralobul...
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#1Christopher J. Schwartz (MSK: Memorial Sloan Kettering Cancer Center)
#2Fresia Pareja (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 20
Last. Hannah Y Wen (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 14
view all 9 authors...
The SWI/SNF family of proteins is a multisubunit ATPase complex frequently altered in human cancer. Inactivating mutations in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin (SMARCs) underpin a subset of tumors such as the malignant rhabdoid tumor and small cell carcinoma of the ovary, hypercalcemic type. Here, we investigated the genotypic and phenotypic characteristics of breast cancers harboring somatic genetic alterations affecting genes of the SMARC family. We analy...
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#1Ian A. Cree (IARC: International Agency for Research on Cancer)H-Index: 59
#2Puay Hoon Tan (SGH: Singapore General Hospital)H-Index: 74
Last. Richard A. Scolyer (RPA: Royal Prince Alfred Hospital)H-Index: 104
view all 8 authors...
Mitoses are often assessed by pathologists to assist the diagnosis of cancer, and to grade malignancy, informing prognosis. Historically, this has been done by expressing the number of mitoses per n high power fields (HPFs), ignoring the fact that microscope fields may differ substantially, even at the same high power (×400) magnification. Despite a requirement to define HPF size in scientific papers, many authors fail to address this issue adequately. The problem is compounded by the switch to ...
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#1Emilio Madrigal (Harvard University)H-Index: 6
#2Long Phi Le (Harvard University)
Macroscopic examination of surgical pathology and autopsy cases is a fundamental component of anatomic pathology. The photographic documentation of such clinical specimens is essential, and it may be required in certain instances. Our department began using consumer-grade digital cameras in 2005 to improve the practice of gross photography. However, the lack of an application to correctly catalog the photographs resulted in thousands of digital image files scattered across shared network drives,...
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#1Stefania Caramaschi (University of Modena and Reggio Emilia)H-Index: 1
#2Meghan E. Kapp (VUMC: Vanderbilt University Medical Center)H-Index: 8
Last. Giovanna A. Giannico (VUMC: Vanderbilt University Medical Center)H-Index: 17
view all 10 authors...
The severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) pandemic has had devastating effects on global health and worldwide economy. Despite an initial reluctance to perform autopsies due to concerns for aerosolization of viral particles, a large number of autopsy studies published since May 2020 have shed light on the pathophysiology of Coronavirus disease 2019 (COVID-19). This review summarizes the histopathologic findings and clinicopathologic correlations from autopsies and biopsies...
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#1Sylvia L. Asa (University Hospitals of Cleveland)H-Index: 115
#2Ozgur Mete (UHN: University Health Network)H-Index: 34
Last. Shereen Ezzat (UHN: University Health Network)H-Index: 64
view all 12 authors...
The classification of adenohypophysial neoplasms as "pituitary neuroendocrine tumors" (PitNETs) was proposed in 2017 to reflect their characteristics as epithelial neuroendocrine neoplasms with a spectrum of clinical behaviors ranging from small indolent lesions to large, locally invasive, unresectable tumors. Tumor growth and hormone hypersecretion cause significant morbidity and mortality in a subset of patients. The proposal was endorsed by a WHO working group that sought to provide a unified...
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#1Jennifer A. Bennett (U of C: University of Chicago)H-Index: 10
#2Zehra Ordulu (Harvard University)H-Index: 10
Last. Esther Oliva (Harvard University)H-Index: 86
view all 13 authors...
Herein we evaluated a series of 21 embryonal rhabdomyosarcomas of the uterine corpus (ucERMS), a rare neoplasm, to characterize their morphology, genomics, and behavior. Patients ranged from 27 to 73 (median 52) years and tumors from 4 to 15 (median 9) cm, with extrauterine disease noted in two. Follow-up (median 16 months) was available for 14/21 patients; nine were alive and well, four died of disease, and one died from other causes. Most tumors (16/21) showed predominantly classic morphology,...
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