European Journal of Hybrid Imaging
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Multiple myeloma is characterized by malignant proliferation of clonal plasma cells. Usually, appears as a generalized disease but it can present as solitary bone plasmacytoma or a solitary soft tissue mass or extramedullary plasmacytoma. In the case of extramedullary involvement, it could present as soft tissue plasmacytomas and the prognosis is poor. The 18F-FDG PET/CT could be a valuable tool for characterization of the medullary and extramedullary involvement. We present a case of F18-FDG PE...
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#1Charlotte Hornnes (UCPH: University of Copenhagen)
#2Annika Loft (UCPH: University of Copenhagen)H-Index: 55
Last. Flemming L. Andersen (UCPH: University of Copenhagen)H-Index: 25
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[18F]Fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) is used for response assessment during therapy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Clinicians report the scans visually using Deauville criteria. Improved performance in modern PET/CT scanners could allow for a reduction in scan time without compromising diagnostic image quality. Additionally, patient throughput can be increased with increasing cost-effectiveness. We investigated the effe...
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#1Knut Johannessen (NTNU: Norwegian University of Science and Technology)
#2Erik Magnus Berntsen (NTNU: Norwegian University of Science and Technology)H-Index: 12
Last. Live Eikenes (NTNU: Norwegian University of Science and Technology)H-Index: 17
view all 6 authors...
Patients with metastatic cancer to the brain have a poor prognosis. In clinical practice, MRI is used to delineate, diagnose and plan treatment of brain metastases. However, MRI alone is limited in detecting micro-metastases, delineating lesions and discriminating progression from pseudo-progression. Combined PET/MRI utilises superior soft tissue images from MRI and metabolic data from PET to evaluate tumour structure and function. The amino acid PET tracer 18F-FACBC has shown promising results ...
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#1Michael Farrell (Walter Reed National Military Medical Center)
#2Gina Hyun (Walter Reed National Military Medical Center)
Last. Pavel Krapiva (Walter Reed National Military Medical Center)
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This case series explores the utility of positron emission tomography (PET)/computed tomography (CT) guidance for biopsy of 18F-fludeoxyglucose (FDG)-avid osseous lesions that are inconspicuous on CT. PET/CT-guided core biopsies were performed in four patients with suspected malignancies given 18F-FDG-avid osseous lesions that were inconspicuous on CT alone. The final diagnosis for each patient was determined by histopathological and molecular testing. PET/CT-guided biopsy yielded accurate sampl...
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#1Tsubasa Okazaki (Tokyo Medical and Dental University)
#2Kota Yokoyama (Tokyo Medical and Dental University)
Last. Ukihide Tateishi (Tokyo Medical and Dental University)H-Index: 50
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SMARCA4-deficient thoracic tumor (SMARCA4-DTT) is a distinct entity of undifferentiated thoracic malignancies newly introduced in 2015. Due to its unique clinical characteristic with aggressive thoracic tumor mostly observed in heavy smoker man with emphysema, with poor prognosis, many physicians are becoming increasingly aware of the disease; however, reports on 2-deoxy-2-[18F] fluoroglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) have been limited; thus, this disease...
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#2Bruno MaucheratH-Index: 2
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BackgroundThe vaccination immune response may induce false-positive 18F-FDG PET/CT uptake Case presentationAn extended supraclavicular lymph nodal activation after coronavirus disease 2019 (COVID-19) vaccination revealed on 18F-FDG PET/CT mimics a Virchow nodule in a patient with medical history of well-differentiated appendicular adenocarcinoma ConclusionThis case highlights a nodal activation beyond axillary area and the importance of documenting vaccination history at the time of scanning to ...
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#1Sofia KvernbyH-Index: 3
#2Nafsika Korsavidou Hult (Uppsala University)H-Index: 2
Last. Mark LubberinkH-Index: 55
view all 9 authors...
Respiratory motion during PET imaging reduces image quality. Data-driven gating (DDG) based on principal component analysis (PCA) can be used to identify respiratory signals. The use of DDG, without need for external devices, would greatly increase the feasibility of using respiratory gating in a routine clinical setting. The objective of this study was to evaluate data-driven gating in relation to external hardware gating and regular static image acquisition on PET-MRI data with respect to SUVm...
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#1Nicolas Nicastro (University of Cambridge)H-Index: 12
#2Negin Holland (University of Cambridge)H-Index: 3
Last. John T. O'Brien (University of Cambridge)H-Index: 133
view all 11 authors...
Objective Dementia with Lewy bodies (DLB) is a common cause of dementia, but atrophy is mild compared to Alzheimer's disease. We propose that DLB is associated instead with severe synaptic loss, and we test this hypothesis in vivo using positron emission tomography (PET) imaging of 11C-UCB-J, a ligand for presynaptic vesicle protein 2A (SV2A), a vesicle membrane protein ubiquitously expressed in synapses. Methods We performed 11C-UCB-J PET in two DLB patients (an amyloid-negative male and an amy...
2 CitationsSource
This brief review summarizes the major applications of artificial intelligence (AI), in particular deep learning approaches, in molecular imaging and radiation therapy research. To this end, the applications of artificial intelligence in five generic fields of molecular imaging and radiation therapy, including PET instrumentation design, PET image reconstruction quantification and segmentation, image denoising (low-dose imaging), radiation dosimetry and computer-aided diagnosis, and outcome pred...
16 CitationsSource
#1Tessel M. Boertien (UvA: University of Amsterdam)H-Index: 2
#2Jan Booij (UvA: University of Amsterdam)H-Index: 69
Last. Eric Fliers (UvA: University of Amsterdam)H-Index: 67
view all 11 authors...
Clinically non-functioning pituitary macroadenomas (NFMA) have been reported to express somatostatin receptors (SSTR), but results are inconsistent across different studies. This may be related to limited sensitivity and specificity of techniques used to date, i.e. immunohistochemistry in surgical specimens and 111In-DTPA-octreotide scintigraphy in vivo. The aim of this study was to assess SSTR expression in NFMA in vivo using 68Ga-DOTATATE PET, which offers superior sensitivity and spatial reso...
1 CitationsSource
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Radiology
PET-CT
Positron emission tomography
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