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#1Agata Blasiak (NUS: National University of Singapore)H-Index: 6
#2Anh T.L. Truong (NUS: National University of Singapore)H-Index: 1
Last. Teo St (NUS: National University of Singapore)
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ObjectivesWe aimed to harness IDentif.AI 2.0, a clinically actionable AI platform to rapidly pinpoint and prioritize optimal combination therapy regimens against COVID-19. MethodsA pool of starting candidate therapies was developed in collaboration with a community of infectious disease clinicians and included EIDD-1931 (metabolite of EIDD-2801), baricitinib, ebselen, selinexor, masitinib, nafamostat mesylate, telaprevir (VX-950), SN-38 (metabolite of irinotecan), imatinib mesylate, remdesivir, ...
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#1Whittaker R (FHI: Norwegian Institute of Public Health)H-Index: 1
#2Kristofferson AbH-Index: 1
Last. Karoline Bragstad (FHI: Norwegian Institute of Public Health)H-Index: 15
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BackgroundThe SARS-CoV-2 variant of concern (VOC) B.1.1.7 has spread worldwide and has been associated with increased risk of severe disease. Studies on patient trajectories and outcomes among hospitalised patients infected with B.1.1.7 are essential for hospital capacity planning. MethodsUsing linked individual-level data from national registries, we conducted a cohort study on cases of SARS-CoV-2 in Norway hospitalised between 21 December 2020 and 25 April 2021. We calculated adjusted hazard r...
1 CitationsSource
#2Gergely Lh (Semmelweis University)
Last. Sardy M (Semmelweis University)
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Objectives: A compact handheld skin ultrasound imaging device has been developed that uses co-registered optical and ultrasound imaging to provide diagnostic information about the full skin depth and lesions encountered therein. The aim of the current work is to present the first clinical results of the device. Using additional photographic, dermoscopic and ultrasonic images as reference, the images from the device are assessed in terms of the detectability of the skin layer boundaries (between ...
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#1Anna Ostropolets (Columbia University)H-Index: 5
#2Xintong Li (University of Oxford)H-Index: 5
Last. Patrick B. Ryan (Janssen Pharmaceutica)H-Index: 40
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Background Background incidence rates are routinely used in safety studies to evaluate an association of an exposure and outcome. Systematic research on sensitivity of rates to the choice of the study parameters is lacking. This study investigates the influence of study parameter choices on background rates of adverse events. Methods We used 12 electronic health record and administrative claims data sources to calculate incidence rates of 15 adverse events. We examined the influence of age, race...
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#1Niamh McCombeH-Index: 3
#2Xuemei DingH-Index: 10
Last. KongFatt Wong-LinH-Index: 19
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ObjectiveDespite the potential of machine learning techniques to improve dementia diagnostic processes, research outcomes are often not readily translated to or adopted in clinical practice. Importantly, the cost of assessment items, in terms of assessment time, has yet to be taken into account in feature-selection based optimisation for dementia diagnosis. We address these issues by considering the impact of assessment time as a practical constraint for feature selection of cognitive and functi...
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#1Sheila F Lumley (University of Oxford)H-Index: 16
#2Bede Constantinides (University of Oxford)H-Index: 6
Last. Sarah J. Hoosdally (University of Oxford)H-Index: 18
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BackgroundDespite robust efforts, patients and staff acquire SARS-CoV-2 infection in hospitals. In this retrospective cohort study, we investigated whether whole-genome sequencing (WGS) could enhance the epidemiological investigation of healthcare-associated SARS-CoV-2 acquisition. Methods and findingsFrom 17-November-2020 to 5-January-2021, 803 inpatients and 329 staff were diagnosed with SARS-CoV-2 infection across four teaching hospitals in Oxfordshire, UK. We classified cases according to ep...
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#1Alistair Thorpe (UofU: University of Utah)H-Index: 4
#2Angela Fagerlin (UofU: University of Utah)H-Index: 66
Last. Laura D. Scherer (University of Colorado Denver)H-Index: 21
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Purpose. Beliefs that the risks from the vaccine outweigh the risks from getting COVID-19 and concerns that the vaccine development process was rushed and lacking rigor have been identified as important drivers of hesitancy and refusal to get a COVID-19 vaccine. We tested whether messages designed to address these beliefs and concerns might promote intentions to get a COVID-19 vaccine. Method. An online survey fielded between March 8-March 23, 2021 with US Veteran (n=688) and non-Veteran (n=387)...
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Objective: null To compare hypoxemia severity of patients with COVID-19 pneumonia that arrive at an emergency department as classified by three oxygenation indexes. Design: Retrospective analysis of pulse oximeter saturation and arterial blood gas analysis obtained at arrival. Setting: Tertiary referral hospital in Mexico City converted early in the pandemic to a COVID-19 center. Patients and measurements: A total of 2,960 patients with suspected COVID-19 pneumonia were admitted to the emergency...
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#1Macha Dubuson (ULB: Université libre de Bruxelles)H-Index: 1
#2Charles Kornreich (ULB: Université libre de Bruxelles)H-Index: 34
Last. Armand Chatard (University of Poitiers)H-Index: 16
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BackgroundApproximately half the people with alcohol use disorder (AUD) relapse into alcohol reuse in the few weeks following withdrawal treatment. Brain stimulation and cognitive training represent recent forms of complementary interventions in the context of AUD. null ObjectiveTo evaluate the clinical efficacy of transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) combined with alcohol cue inhibitory control training (ICT) as part of rehabilitation. n...
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#1Neil J. Meigh (Bond University)H-Index: 1
#2Justin W L Keogh (AUT: Auckland University of Technology)H-Index: 53
Last. Evelyne Rathbone (Bond University)H-Index: 4
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The Ballistic Exercise of the Lower Limb (BELL) trial examined efficacy and safety of a pragmatic hardstyle kettlebell training program in older adults. Insufficiently active men and women aged 59-79 years, were recruited to a 6-month repeated measures study, involving 3-months usual activity and 3-months progressive hardstyle kettlebell training. Health-related physical fitness outcomes included: grip strength [GS], 6-min walk distance [6MWD], resting heart rate [HR], stair-climb [SC], leg exte...
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