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#1Murdani Abdullah (UI: University of Indonesia)H-Index: 16
#2Ninik Sukartini (UI: University of Indonesia)H-Index: 2
Last. Kaka Renaldi (UI: University of Indonesia)H-Index: 4
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BACKGROUND Researchers believe the role of gut microbiota dysbiosis in the raised incidence of early-onset colorectal cancer (EOCRC). The development of EOCRC may be associated with microbiota dysbiosis either dependently or independently (combined with other risk factors). SUMMARY Recently, the rising of incidence and mortality of EOCRC have been noted. Some researchers are looking for risk factors influencing this fact. They hypothesize that it may be because of microbiota dysbiosis. Microbiot...
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#2Yusuke HoriuchiH-Index: 13
Last. Junko FujisakiH-Index: 27
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#1Yutaro Ihara (Kyushu University)
#2Takehiro Torisu (Kyushu University)H-Index: 15
Last. Takeshi Sugio (Kyushu University)H-Index: 5
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Background null Ustekinumab (UST), an antibody targeting the p40 subunit of interleukin (IL)-12 and IL-23, is effective in treating Crohn's disease (CD). To clarify the mechanism of UST, we investigated T-cell differentiation in CD patients treated with UST. null Methods null Twenty-seven patients with active CD were enrolled in this study. Seventeen patients were treated with UST, and 10 patients were treated with anti-tumor necrosis factor (TNF)-alpha therapy. The changes in the proportions of...
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#1Shunichi Yanai (Iwate Medical University)H-Index: 13
#2Shinichiro Shinzaki (Osaka University)H-Index: 23
Last. Takayuki Matsumoto (Iwate Medical University)H-Index: 66
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INTRODUCTION The aim of this study was to examine whether biomarkers are predictive of the adalimumab (ADA) trough level and antidrug antibody development in patients with Crohn's disease (CD) and ulcerative colitis (UC). METHODS Using data obtained in a prospective, multicenter, observational study (PLANET), we assessed serial changes in a novel biomarker - leucine-rich alpha-2 glycoprotein (LRG) - during ADA treatment for patients with active CD and UC. We measured serum LRG, C-reactive protei...
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#1Haruna Miyashita (Jikei University School of Medicine)
#2T Yamasaki (Jikei University School of Medicine)H-Index: 3
Last. Toshiyuki Sakurai (Jikei University School of Medicine)H-Index: 17
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BACKGROUND AND AIMS In gastrointestinal neuroendocrine tumors (GI-NETs), tumor size and grading based on cellular proliferative ability indicate biological malignancy but not necessarily clinically efficient prognostic stratification. We analyzed tumor size- and grading-based prevalence of lymphovascular invasion in GI-NETs to establish whether these are true biological malignancy indicators. METHODS We included 155 cases (165 lesions), diagnosed histologically with GI-NETs, that had undergone e...
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#1Kentaro Ochiai (UTokyo: University of Tokyo)H-Index: 1
#2Kazushige Kawai (UTokyo: University of Tokyo)H-Index: 30
Last. Shinichi Yamauchi (Tokyo Medical and Dental University)H-Index: 5
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INTRODUCTION Multiple primary malignancies (MPMs) are likely to develop in patients with colorectal cancer (CRC); however, their prognoses are unclear. This study aims to investigate the prognostic impacts and clinicopathological features of multiple CRCs and extracolorectal malignancies (EMs) with CRC. METHODS We retrospectively evaluated a total of 22,628 patients with stage I-III CRC who underwent curative resection at 24 referral institutes in Japan between January 2004 and December 2012. MP...
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#1Toshihiro NishizawaH-Index: 28
#2Shuntaro Yoshida (UTokyo: University of Tokyo)H-Index: 19
Last. Kazuhiko Koike (UTokyo: University of Tokyo)H-Index: 91
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BACKGROUND The diagnostic clues for autoimmune gastritis (AIG) can be classified into 2 categories: endoscopic findings and pathological diagnosis. We believe that research on the AIG detection rate by endoscopists could provide a better understanding of the diagnosis of AIG. This study aimed to clarify the ratio of the endoscopic and the pathological diagnoses of AIG. METHODS We retrospectively reviewed consecutive patients who underwent esophagogastroduodenoscopy (EGD). During their first EGD,...
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#1Takashi Hirose (Nagoya University)H-Index: 1
#2Naomi Kakushima (Nagoya University)H-Index: 24
Last. Eizaburo Ohno (Nagoya University)H-Index: 21
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INTRODUCTION Endoscopic criteria for the diagnosis of superficial nonampullary duodenal epithelial tumors (SNADETs) are lacking. The aim of this study was to explore the usefulness of endocytoscopy (ECS) in the duodenum. METHODS A total of 77 ECS images stained by methylene blue and 58 images with double staining of methylene blue and crystal violet were obtained from 20 patients. Images were classified into 3 grades based on nuclear and villi atypia: EC A, B, and C. Diagnostic performance of EC...
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#2Ryoji MiyaharaH-Index: 21
Last. Mitsuhiro Fujishiro (Nagoya University)H-Index: 64
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Introduction Dysphagia is a common symptom that occurs in patients with diabetes mellitus (DM). There have been few prospective observational studies on esophageal motility disorders in DM using high-resolution manometry (HRM). This study aimed to clarify the characteristics of esophageal motility disorders using HRM in patients with dysphagia and compare them between DM and non-DM patients. Methods Patients with dysphagia were prospectively recruited between October 2018 and July 2019. Patients...
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#1Tomohiko Suzuki (Nagoya University)
#2Kazuhiro Furukawa (Nagoya University)H-Index: 11
Last. Mitsuhiro Fujishiro (Nagoya University)H-Index: 64
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INTRODUCTION Patients with esophageal squamous cell carcinoma (ESCC) have various comorbidities. Thus, it is necessary to determine the appropriateness of performing treatment based on the patient's general condition. AIM This study aimed to clarify the prognostic predictors of ESCC indicated for endoscopic submucosal dissection (ESD). METHODS This retrospective study enrolled 241 patients with superficial ESCC endoscopically diagnosed as ESD-indicated lesions at the Nagoya University Hospital b...
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Endocrinology
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Gynecology
Diabetes mellitus
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