BMJ Open Gastroenterology
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249
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#1Andrew Kei-Yan Ng (Grantham Hospital)H-Index: 5
#2Pauline Yeung Ng (HKU: University of Hong Kong)
Last. Chung-Wah Siu (HKU: University of Hong Kong)H-Index: 60
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Background null Previous studies showing an association between chronic use of proton pump inhibitor (PPI) and gastric cancer are limited by confounding by indication. This relationship has not been studied in patients receiving PPI for prophylaxis, such as those undergoing percutaneous coronary intervention (PCI). null Method null This was a retrospective cohort study including 14 hospitals under the Hospital Authority of Hong Kong between 1 January 2004 and 31 December 2017. Participants were ...
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#1Chris Poyner (University of Birmingham)
#2Dhiraj Tripathi (University of Birmingham)H-Index: 2
Last. Jonathan MathersH-Index: 9
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Background null The most common fatal complication of liver cirrhosis is haemorrhaging caused by variceal rupture. The prevention of the first variceal bleed is, therefore, an important clinical goal. Little is known about patients’ experience of treatments geared towards this, or of their perceptions of treatments prior to being exposed to them. null Aims null To explore the factors impacting patient preference for, and actual experience of carvedilol and variceal band ligation. null Methods nu...
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#1Kathy Weisel (GSK: GlaxoSmithKline)
#2Nicola Scott (GSK: GlaxoSmithKline)H-Index: 5
Last. Susan W. Burriss (GSK: GlaxoSmithKline)H-Index: 3
view all 13 authors...
OBJECTIVE Tumour necrosis factor signalling via the receptor-interacting protein kinase 1 (RIPK1) pathway regulates colonic inflammation suggesting that RIPK1 inhibition may be a potential therapeutic target in ulcerative colitis (UC). This phase IIa, randomised, double-blind experimental medicine study investigated the safety, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary efficacy of the RIPK1 inhibitor GSK2982772 in patients with active UC. DESIGN In part A, prior to a protocol ...
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#1Ben Glover (Imperial College London)H-Index: 3
#2Julian Teare (Imperial College London)H-Index: 25
Last. Nisha Patel (Imperial College London)H-Index: 21
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Objectives null Helicobacter pylori infection is a common cause of chronic gastritis worldwide and an established risk factor for developing gastric malignancy. The endoscopic appearances predicting H. pylori status are an ongoing area of research, as are their diagnostic accuracies. This study aimed to establish the diagnostic accuracy of several mucosal features predictive of H. pylori negative status and formulate a simple prediction model for use at the time of endoscopy. null Design null Pa...
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Hepatitis C virus (HCV) infection is a major public health concern worldwide, raising important medical and economic issues. HCV-related end-stage liver disease is one of the most common indications for hepatic transplantation. Chronic hepatitis C is also assimilated to a systemic disease because of multiple extrahepatic manifestations, including lymphoproliferative disorders. The revolution of HCV treatment with the advent of direct-acting antivirals has significantly improved the management wi...
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#1Pimsiri Sripongpun (MU: Mahidol University)H-Index: 4
#2Ananya Pongpaibul (MU: Mahidol University)H-Index: 7
Last. Phunchai Charatcharoenwitthaya (MU: Mahidol University)H-Index: 12
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OBJECTIVE The decision regarding whether to perform a liver biopsy in patients with cirrhosis and clinically suspected autoimmune hepatitis (AIH) remains a challenge. This study aimed to assess the utility and complications of percutaneous liver biopsy in cirrhosis for differentiating AIH from other liver conditions. METHODS A clinicopathological database of patients undergoing percutaneous liver biopsies for suspected AIH (unexplained hepatitis with elevated γ-globulin and autoantibody seroposi...
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OBJECTIVE Benign liver tumours (BLT) are increasingly diagnosed as incidentalomas. Clinical implications and management vary across and within the different types of BLT. High-quality clinical practice guidelines are needed, because of the many nuances in tumour types, diagnostic modalities, and conservative and invasive management strategies. Yet, available observational evidence is subject to interpretation which may lead to practice variation. Therefore, we aimed to systematically search for ...
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#1Richard Mattock (Ebor: University of York)H-Index: 1
#2Dhiraj Tripathi (University Hospitals Birmingham NHS Foundation Trust)H-Index: 26
Last. Guruprasad P. Aithal (University of Nottingham)H-Index: 62
view all 0 authors...
Objectives null Transjugular intrahepatic portosystemic stent shunt (TIPSS) is clinically effective in variceal bleeding and refractory ascites; however, the cost-effectiveness of TIPSS has yet to be evaluated in the UK. This study aimed to establish the cost-effectiveness of (i) pre-emptive TIPSS versus endoscopic band ligation (EBL) in populations with variceal bleeding and (ii) TIPSS versus large volume paracentesis (LVP) in refractory ascites. null Methods null A cost-utility analysis was co...
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#1Elissa Lynch (Columbia University)H-Index: 1
#2Jordan Troob (Columbia University)
Last. Daniel E. Freedberg (Columbia University)H-Index: 23
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BACKGROUND The rapid growth of the probiotic industry suggests patients will continue to seek advice from gastroenterologists about probiotics. To best address patient questions and concerns, we must first understand who uses probiotics and why. METHODS This was a cross-sectional study conducted in the endoscopy suite of an academic hospital from June to October of 2019. Surveys were anonymous and contained a combination of multiple choice, free text and Likert scale questions. Participants priv...
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#1D. Mark Pritchard (University of Liverpool)H-Index: 30
#2Jan Bornschein (University of Oxford)H-Index: 28
Last. Peter Malfertheiner (Otto-von-Guericke University Magdeburg)H-Index: 21
view all 6 authors...
Objective null Clinical data comparing diagnostic strategies in the management of Helicobacter pylori-associated diseases are limited. Invasive and noninvasive diagnostic tests for detecting H. pylori infection are used in the clinical care of patients with dyspeptic symptoms. Modelling studies might help to identify the most cost-effective strategies. The objective of the study is to assess the cost-effectiveness of a ‘test-and-treat’ strategy with the urea breath test (UBT) compared with other...
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