CEN Case Reports
Papers
483
Papers 619
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#1Midori Awazu (Keio: Keio University)H-Index: 19
#2Mamiko Yamada (Keio: Keio University)H-Index: 3
Last. Kazuya Matsumura (Keio: Keio University)H-Index: 2
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Mutations in the ciliary gene TTC21B, NPHP4, and CRB2 cause familial focal and segmental glomerulosclerosis (FSGS). We report a girl with a mutation of the ciliary gene CC2D2A presenting with FSGS and nephronophthisis. The patient had mental retardation, postaxial polydactyly, and ataxic breathing, and was diagnosed as having compound heterozygous CC2D2A missense mutations at age 5. Retrospectively, azotemia at 1 year and proteinuria at 5 years were recorded but not investigated. At age 6, she w...
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#1Yoko Shirai (Toho University)H-Index: 2
#2Kenichiro MiuraH-Index: 13
Last. Motoshi HattoriH-Index: 31
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Patients with adipsic hypernatremia present with chronic hypernatremia because of defects in thirst sensation and dysregulated salt appetite, without demonstrable hypothalamic structural lesions. The involvement of autoantibodies directed against the sodium channel, Nax in the subfornical organ (SFO) has recently been reported. However, the pathophysiology of water and electrolyte imbalance underlying the disease has yet to be elucidated. We describe the case of a 5-year-old boy who complained o...
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#1Kimio WatanabeH-Index: 12
Last. Masaaki NakayamaH-Index: 41
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Renin-angiotensin-aldosterone system (RAAS) is primarily involved with pathological mechanism of developing hypertensive emergencies. However, none of clinical practice guidelines mention RAAS blockers for the treatment of hypertensive emergencies. A 44 year-old woman presented with severe hypertension, brain stem posterior reversible encephalopathy syndrome and severe acute kidney injury (AKI). We started anti-hypertensive therapy with continuous intravenous nitroglycerin and oral calcium chann...
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#1Sae Aratani (UTokyo: University of Tokyo)
#2Teppei Sugano (Nippon Medical School)H-Index: 8
Last. Yukinao Sakai (Nippon Medical School)H-Index: 6
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Combination therapy, consisting of immune checkpoint inhibitors and traditional chemotherapeutic agents, has significantly improved the clinical outcomes of non-small cell lung cancer. Therefore, it will be a promising first-line therapy, whereas, there is a prospect that associated kidney injury may increase during treatment. We presented four patients, diagnosed with advanced non-small cell lung cancer, who received combination therapy, consisting of pembrolizumab, cisplatin, and pemetrexed as...
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#1Kazumi Komaki (Kyoto Prefectural University of Medicine)H-Index: 2
#2Yayoi Shiotsu (Kyoto Prefectural University of Medicine)H-Index: 8
Last. Takashi Oda (TMU: Tokyo Medical University)H-Index: 17
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A 75-year-old man with fever was diagnosed with alveolar hemorrhage. Antineutrophil cytoplasmic antibodies for myeloperoxidase and proteinase 3 were absent. He received corticosteroid therapy, which immediately improved his symptoms and chest radiological findings. After the discontinuation of corticosteroids, fever and general fatigue relapsed, and renal function deteriorated with hematuria and proteinuria. A nerve conduction study revealed mononeuritis multiplex. Renal biopsy demonstrated foca...
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We report a case of acute ischemic nephropathy in a patient with severe renal artery stenosis and bradycardia due to sick sinus syndrome. An 83-year-old Japanese woman with a history of hypertension was diagnosed with sick sinus syndrome and scheduled for pacemaker implantation. Four days prior to admission for the procedure, she experienced sudden-onset severe right flank pain that persisted for 1 day. On the day of admission, her serum creatinine level increased from 1.35 mg/dL, measured 2 wee...
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#1Ryo TanakaH-Index: 2
#2Koichi TsutaharaH-Index: 7
Last. Tetsuya TakaoH-Index: 20
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Chronic active antibody-mediated rejection (CAAMR) is a frequent cause of late graft loss. However, effective treatment for CAAMR after kidney transplantation has not yet been established. Here, we present the case of a kidney transplant recipient who recovered from CAAMR after administration of rabbit anti-thymocyte globulin. A 61-year-old man underwent ABO-compatible living-donor kidney transplantation for end-stage kidney disease; the kidney was donated by his wife. Five years after the trans...
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#1Yuko OyamaH-Index: 6
#2Yoichi IwafuchiH-Index: 5
Last. Ichiei Narita (Niigata University)H-Index: 55
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Glucocorticoids are widely used for treating underlying renal diseases and following renal transplantation and are often tapered or discontinued upon reaching end-stage renal failure. Although glucocorticoid withdrawal is the predominant cause of secondary adrenal insufficiency, no consensus has been established regarding its prevalence, clinical manifestations, or therapeutic regimen, for prevention of this pathological condition. We describe a 29-year-old woman admitted to our hospital because...
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#1Rikako Oki (UTokyo: University of Tokyo)H-Index: 1
#2Yosuke Hirakawa (UTokyo: University of Tokyo)H-Index: 9
Last. Masaomi Nangaku (UTokyo: University of Tokyo)H-Index: 80
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Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) had clinical success in the treatment of non-small cell lung carcinoma (NSCLC). An effect of this drug on kidney has not been clarified and the occurrence of glomerulonephritis related to EGFR-TKI has rarely been reported. We present the case of a 71-year-old man with NSCLC who developed proteinuria and microscopic hematuria with the rise in a titer of MPO-ANCA, when 2 years and 3 months passed since the initiation of erloti...
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#1Kosei Yamaguchi (Nagasaki University)
#2Mineaki Kitamura (Nagasaki University)H-Index: 6
Last. Hideki Sakai (Nagasaki University)H-Index: 24
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Wiskott-Aldrich syndrome (WAS) is an X-chromosome recessive immunodeficiency disease characterized by the triad of thrombocytopenia, eczema, and susceptibility to infection owing to WAS protein gene abnormalities. Kidney transplantation is rarely offered to WAS patients with end-stage renal disease because of concerns that thrombocytopenia and immune disorders may affect the clinical outcome. Here, we report the case of a 20-year-old kidney transplant patient who developed end-stage renal diseas...
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Top fields of study
Surgery
Pathology
Renal biopsy
Nephrology
Medicine
Gastroenterology