Journal of orthopaedic translation
Papers 732
1 page of 74 pages (732 results)
#1Timothy Dreyer (University of Pretoria)
#2Mittal Shah (UCB)
Last. Gill Holdsworth (UCB)H-Index: 9
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Background null Sclerosteosis, a severe autosomal recessive sclerosing skeletal dysplasia characterised by excessive bone formation, is caused by absence of sclerostin, a negative regulator of bone formation that binds LRP5/6 Wnt co-receptors. Current treatment is limited to surgical management of symptoms arising from bone overgrowth. This study investigated the effectiveness of sclerostin replacement therapy in a mouse model of sclerosteosis. null null null Methods null Recombinant wild type m...
#1Xianfa Du (SYSU: Sun Yat-sen University)H-Index: 2
#2Haitao Cui (SYSU: Sun Yat-sen University)H-Index: 1
Last. Yong-Can Huang (PKU: Peking University)
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Abstract null null Objective null Low back pain is a leading cause of disabilities worldwide, and intervertebral disc degeneration (IVDD)-related disorders have been recognised as one of the main contributors. Nevertheless, the underlying mechanism has not yet been fully understood. The aim of this study was to investigate the role of the miR-133a-5p/FBXO6 axis in the regulation of IVDD. null null null Methods null RT-qPCR, WB and IHC were performed to assess the expression of FBXO6 in human IVD...
#1Lin Xu (Guangxi Medical University)H-Index: 1
#2Hao QinH-Index: 1
Last. Wenhua Huang (Guangxi Medical University)H-Index: 22
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Abstract null null Background null /Objective: In recent years, prostheses have been widely used for limb reconstruction after pelvic tumour resection. However, prostheses are associated with problems leading to tumour recurrence, poor implant matching, defects after tumour resection, and easy implant looseness or failure. To achieve a precise preoperative design, complete tumour resection, and better anatomical structure matching and prosthesis stability, this study used three-dimensionally (3D...
#1Kwok Chuen Wong (CUHK: The Chinese University of Hong Kong)H-Index: 16
#2Louis Kwan Yik Sze (CUHK: The Chinese University of Hong Kong)H-Index: 1
Last. Shekhar M. Kumta (CUHK: The Chinese University of Hong Kong)H-Index: 30
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Abstract null null In selected extremity bone sarcomas, joint-preserving surgery retains the natural joints and nearby ligaments with a better function than in traditional joint-sacrificing surgery. Geometric multiplanar osteotomies around bone sarcomas were reported with the advantage of preserving more host bone. However, the complex surgical planning translation to the operating room is challenging. null Using both Computer Navigation and Patient-Specific Guide may combine each technique's ke...
#1Runzhi Xia (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Zanjing Zhai (SJTU: Shanghai Jiao Tong University)H-Index: 24
Last. Mengning Yan (SJTU: Shanghai Jiao Tong University)H-Index: 9
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Abstract null null Objective null To evaluate accuracy of an innovative “Skywalker” system, a newly designed, robot-assisted operation system for orthopaedics via a clinical trial at knee joint. null null null Methods null We conducted a prospective analysis of the clinical data of 31 patients who underwent total knee arthroplasty assisted by the “Skywalker” robot (Microport, Suzhou, China) from June 2020 to January 2021. Five male patients and 26 female patients aged 69.68 ​± ​6.11 years (range...
#1Kenneth Lo (PolyU: Hong Kong Polytechnic University)H-Index: 9
#2Manting Au (PolyU: Hong Kong Polytechnic University)
Last. Chunyi Wen (PolyU: Hong Kong Polytechnic University)H-Index: 20
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Abstract null null Objective null Literature examining the relationship between elevated blood pressure and osteoarthritis (OA) has yielded conflicting results. This study aimed to systematically review the relationship between hypertension and OA in both load-bearing and non-load-bearing joints. null null null Methods null A systematic literature search was performed on Embase, Emcare, MEDLINE and Ovid Nursing Database. The associations between hypertension and OA development in knees, hips and...
#2Xiaolin Xu (Peking Union Medical College Hospital)
#1Yiyang Ma (SJTU: Shanghai Jiao Tong University)
#2Kaiwen Zheng (SJTU: Shanghai Jiao Tong University)
Last. Dajiang Du (SJTU: Shanghai Jiao Tong University)H-Index: 1
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Abstract null null Background null Costal chondrocytes (CCs), as a promising donor cell source for cell-based therapy for cartilage repair, have strong tendency of hypertrophy and calcification, which limited CCs from further application in cartilage regenerative medicine. Synovium-derived stromal cells (SDSCs), have shown their beneficial effect for chondrocytes to maintain phenotype. This study aims to investigate whether SDSCs could help CCs to maintain chondrogenic phenotype and suppress hyp...
Abstract null null Background null The function of H3F3A G43W mutation, which has been observed in almost all GCTB, remains poorly characterized. Breakthrough in malignant GCTB has been trapped by the lack of clinical available drugs, limited canonical patient samples and paucity of fidelity preclinical models. null null null Methods null Tumor samples obtained from a malignant GCTB was implanted in immunodeficient mice for the generation of PDX. Histological examination and short tandem repeat ...
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